The antiulcer activity of an aqueous extract of Pyrenacantha staudtii was studied in rats and was compared with that of cimetidine. Ulcers were induced in rats by means of various experimental models: aspirin, indomethacin, serotonin and reserpine. The extract was found to have significant antiulcer activity against all the models studied. Cimetidine was found to be ineffective against serotoni...

Introduction. Breast cancer resistance protein (BCRP) is an efflux membrane transporter that controls the pharmacokinetics of a large number drugs. Its activity may change when taking some endo- and exogenous substances, thus making it link in drug interactions. Aim. The aim study was to develop method for testing drugs belonging BCRP substrates inhibitors vitro. Materials methods. work perform...

Certain Rauwolfia alkaloids (reserpine, rescinnamine,serpentine, ajmaline and ajmalicine) were investigated for their central vasodepressant effects in cats. 5-Hydroxytryptamine was included in this study because it has been implicated as a mediator in the action ofreserpine and rescinnamine. Pressor responses were elicited from the medullary vasopressor locus with the steriotaxic technic, and ...

The benzofuran antiarrhythmic drug, amiodarone, exhibits a wide range of pharmacological properties. Recent in vivo biochemical studies suggest that amiodarone may exert an antiadrenergic action in the heart, which resembles the effects of reserpine. To investigate the cellular basis for this apparent presynaptic, sympatholytic action we used Chinese hamster ovary (CHO) cells expressing the typ...

The effect of catecholamine depletion (induced by prior treatment with reserpine) was studied in Wistar rat ventricular myocytes using whole cell voltage-clamp methods. Two calcium-independent outward currents, the transient outward potassium current (I(to)) and the sustained outward potassium current (I(sus)), were measured. Reserpine treatment decreased tissue norepinephrine content by 97%. A...

樽 口 秀雄 ・松尾 高明 ・中谷〓 二 ・島本 暉朗 One of the side actions which restrict the clinical use of reserpine is a strong and long-lasting mental depression. Looking for other reserpine-like alkaloids less toxic and more useful for clinical trials than reserpine, Velluz et al. (1, 2) have presented 10 methoxydeserpidine (decaserpine), an isomer of reserpine . The pharmacological effects of decaserpine have ...

The objective of the present study was to make comparison between rat models of depression achieved by chronic unpredictable mild stress (CUMS) and reserpine injection from the angle of traditional Chinese medicine syndrome, depict the regularity of syndrome variation of the two models, and preliminarily explain its molecular mechanism. Rat depression models were achieved respectively by CUMS a...

Root extracts of Rauwolfia serpentina have been used for centuries in Ayurvedic medicine as a panacea for a wide variety of physical as well as mental disorders. The potential of Agrobacterium rhizogenes-mediated genetic transformation for the synthesis of phytomolecules of high pharmaceutical value is now well established and documented. Transgenic roots were induced from R. serpentina leaf ex...