background: the presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. however, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. objective: to study microchimerism in a group of kidney transplant recipi...

heart failure is common in patients with chronic renal disease, either as a complication of renal failure or from shared risk factors, or is the major cause of death in patients on dialysis. at present, end stage renal disease (esrd) patients who have systolic heart failure are considered high-risk for surgery; and nephrologists and cardiologists are reluctant to refer these patients for kidney...

there are wide individual differences in pharmacokinetic parameters of mycophenolate mofetil (mmf) among transplanted patients. some studies have shown that single nucleotide polymorphisms (snps) of the uridine diphosphate glucuronosyl transferase1a9 (ugt1a9) are responsible for these differences in early days after transplantation. therefore it was decided to evaluate the influence of ugt poly...

Recognition of the natural history and responsible leading factors for regression of left ventricular hypertrophy after successful renal transplantation are very important. The aim of this study was to assess the regression of left ventricular hypertrophy after successful renal transplantation among uremic patients. In this study 27 uremic patients (18 males and 9 females) with an average a...

results implementation of modern techniques of immune monitoring, allograft function, awareness about the specific infectious and non-infectious disease in each region improves the quality of renal transplantation. conclusions we need to combine the advance scientific vision with local vigilance to achieve the best outcome in renal allograft recipients evidence acquisitions in this process we s...

The origin of the recipient is one recipient-related factors that statistically significantly affects outcomes kidney transplantation, but this factor not so relevant in our country. article presents first experience transplantation a patient African descent at N.I. N.V. Sklifosovsky. Material and methods . Allogeneic renal graft from post-mortem donor was performed 60-year-old male with stage ...

bk virus (bkv) is a polyomavirus with seroprevalence in adults, ranging from 60 to 100%. it is considered as usual cause of renal dysfunction after the allograft renal transplantation nephropathy. potent immunosuppressive therapy in kidney transplantation can lower the rate of acute rejection. therefore, untreated bkv infections lead to kidney allograft dysfunction or loss. in order to estimate...

In 2003, more than 320,000 people in the United States were receiving dialysis for ESRD, with predicted increases to 650,000 by 2010 and 2 million by 2030. Mortality from cardiovascular disease (CVD) in patients with ESRD is 10 to 30 times higher than in the general population. The exact mechanism of accelerated CVD in patients with kidney disease is unknown. Treatment costs for ESRD are in exc...

Despite progress in preventing and controlling infectious complications of renal transplantation, posttransplantation viral infections remain a significant threat to patients’ health. Optimizing outcomes after renal transplantation depends on effective management of posttransplant infectious complications. This paper discusses manifestations, prevention, diagnosis, and treatment of common viral...