Traumatic events generate some of the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most efficacious treatments to diminish recent (i.e., day-old) traumata capitalize on memory updating mechanisms during reconsolidation that are initiated upon memory recall. Here, we ...

In this paper, we propose a remote healing approach for computer systems based on backdoors, a system architecture that supports monitoring and repair actions on a remote operating system or application memory image without using the processors of the target machine. A backdoor can be implemented using the remote memory communication technology provided by communication standards like Virtual I...

Efficient sharing of memory resources in a cluster of workstations has the promise of greatly improving the performance and cost-effectiveness of the cluster when running large memoryintensive jobs. A point of interest is the hardware support required for good memory sharing performance. We evaluate the performance of two models: the software-only model that runs on a traditional distributed sy...

In distributed shared memory multiprocessors, remote memory accesses generate processor-tomemory traffic which may result in a bottleneck. It is therefore important to design algorithms that minimize the number of remote memory accesses. We establish a lower bound of 3 on remote access time complexity for mutual exclusion algorithms in a model where processes communicate by means of a general r...

Previous studies have shown that medial prefrontal cortical regions, such as the anterior cingulate cortex (ACC), play a key role in the expression of remote spatial and contextual memory. To evaluate whether this role is conserved in hippocampal-independent tasks we trained mice in the conditioned taste aversion (CTA) paradigm. Lidocaine-induced inactivation of the ACC blocked the expression o...

Recently, there has been renewed interest in the organization and neurobiology of remote memory, and the pace of work in this area has accelerated. Yet the recent literature does not suggest that a consensus is developing, and there is disagreement about both facts and their interpretation. This article undertakes a comprehensive review of the three kinds of evidence that have been most promine...

......Contemporary high-performance computing (HPC) systems use the distributed shared-memory (DSM) paradigm, in which the entire memory is logically shared among all the processors but is physically implemented using memory modules distributed across many computing nodes. This approach simplifies programming, provides portability of software, and exhibits improved scalability over traditional ...

The persistent intrusion of remote traumatic memories in people with post-traumatic stress disorder (PTSD) may contribute to the impairment of their ongoing hippocampal and prefrontal cortical functioning. In the current work, we have developed a rodent analogue of the intrusive memory phenomenon. We studied the influence of the activation of a remote traumatic memory in rats on their ability t...

We review lesion and neuroimaging evidence on the role of the hippocampus, and other structures, in retention and retrieval of recent and remote memories. We examine episodic, semantic and spatial memory, and show that important distinctions exist among different types of these memories and the structures that mediate them. We argue that retention and retrieval of detailed, vivid autobiographic...

Participants playing the computer game Tetris reported intrusive, stereotypical, visual images of the game at sleep onset. Three amnesic patients with extensive bilateral medial temporal lobe damage produced similar hypnagogic reports despite being unable to recall playing the game, suggesting that such imagery may arise without important contribution from the declarative memory system. In addi...