DnaA is the widely conserved bacterial AAA+ ATPase that functions as both the replication initiator and a transcription factor. In many organisms, DnaA controls expression of its own gene and likely several others during growth and in response to replication stress. To evaluate the effects of DnaA on gene expression, separate from its role in replication initiation, we analyzed changes in mRNA ...

Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis (Mtb), presenting 9.5 million new cases and 1.5 million deaths in 2014. The aim of this study was to evaluate a nanostructured lipid system (NLS) composed of 10% phase oil (cholesterol), 10% surfactant (soy phosphatidylcholine, sodium oleate), and Eumulgin(®) HRE 40 ([castor oil polyoxyl-40-hydro...

The present study investigates the forest governance structure for REDD+ (Reducing Emissions from Deforestation and Forest Degradation) implementation in a protected forest of Bangladesh, namely Rema-Kalenga Wildlife Sanctuary (RKWS). The study analyses the key aspects of forest governance, focusing on drivers of deforestation and forest degradation, governance deficit, institutions and social ...

El presente estudio se centra en una forma particular de oscurecer la información: situar posición temática sujetos no agentes. hecho adjudicar a sustantivos inanimados un verbo acción proporciona indefensión al receptor, que considera el inevitable si oculta agente realiza. A ello suman otros verbos con agentivos, oscurece u otra manera controla proceso. Esta estrategia debe información coloca...

This paper exploits the sub-district randomization of Indonesia's household Conditional Cash Transfer (CCT) program to analyze how the program a ects the local health care market. The CCT program is associated with increased use of midwives as the main delivery attendants. The program is associated with a 10% increase in both the number of midwives and the delivery fees charged by midwives in t...

Buruli ulcer (BU) is the third most prevalent mycobacteriosis, after tuberculosis and leprosy. The currently recommended combination of rifampicin-streptomycin suffers from side effects and poor compliance, which leads to reliance on local herbal remedies. The objective of this study was to investigate the antimycobacterial properties and toxicity of selected medicinal plants. Sixty-five extrac...

OBJECTIVES To evaluate the performance of three rapid low-cost methods for the detection of resistance to first-line drugs in Mycobacterium tuberculosis. METHODS One hundred M. tuberculosis clinical isolates were tested by the nitrate reductase assay (NRA), the MTT test and the resazurin microtitre assay (REMA), and the results compared with those obtained with the gold standard proportion me...

Purpose: To investigate the therapeutic efficacy of V. diospyroides Symington type LS root extract as a chemopreventive agent against various cancer cell lines. Methods: Acetone root extract was evaluated for in vitro cytotoxicity against KB (oral cavity cancer), MCF-7 (breast cancer), and NCI-H187 (small cell lung cancer), using Resazurin microplate assay (REMA). Toxicity against a representat...