black pepper ( piper nigrum ) from piperaceae and its main ingredient (piperine) reduces gastric emptying in rats. in iranian traditional medicine, black pepper is used to relief the menorrhalgia in women. the aim of this study was to investigate the effect of black pepper fruit aqueous extract on non-pregnant rat uterus contractions and the mechanism(s) of its action. to prepare the extract, b...

OBJECTIVE To investigate the effect of pressure-relief magnitude on heel blood flow. DESIGN 12 healthy subjects (5 male, 7 female; 21 to 43 years of age) lay on a support surface for 50 minutes with 1 heel on the end cell of the support surface. Cell pressure was computer controlled to vary cyclically at 5-minute intervals between a constant 20 mm Hg during loading and 10, 5, and 0 mm Hg duri...

pain relief by soaking in hot water can be used for women who want to birth their child with minimal medical intervention . this achieved in new division of labor in the hinchinbroke hospital in september 1983 . in this part, control of childbirth pain has done with minimal medical intervention . if consultation of maternity is necessary, have be done in this hospital. midwives and doctors in t...

Background. Randomized controlled trials (RCTs) have been conducted comparing the efficacy of rabeprazole 20 mg or omeprazole 20 mg once daily for patients with erosive gastroesophageal reflux disease (GERD). Until now, no study has synthesized all available data examining this issue. Method. Medline, Embase, and the Cochrane central register of controlled trials were searched (through December...

Ongoing efforts to improve clinical trial design in irritable bowel syndrome have been hindered by high placebo response rates and ineffective outcome measures. We assessed established strategies to minimize placebo effect as well as the various ap-proaches to placebo effect which can affect trial design. These include genetic markers such as catechol-O-methyltransferase, opioidergic and dopami...

CONTEXT Main pancreatic duct stones may contribute to pain in chronic pancreatitis. Extracorporeal shock wave lithotripsy (ESWL) has been used alone or in combination with endoscopic therapy for fragmentation of stones. Published studies have shown mixed efficacy due to small sample size. OBJECTIVE Systematic analysis of all published data evaluating ESWL with or without endoscopic therapy in...

INTRODUCTION Endometrial biopsy is necessary for diagnosing the reason of abnormal uterine bleeding in perimenopausal women. Currently outpatient endometrial biopsy is used for evaluation of abnormal uterine bleeding which is associated with moderate to severe pain. Using lidocaine is one of the procedures which is used for pain relief while biopsy. This study is aimed at comparing the effect o...