The goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. Rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. The mesoporous silica nanoparticles were prepared by using Tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); The prepared nanoparti...

Hydrogel based tablets of Simvastatin was formulated using hydropropyl methyl cellulose(different grades), guar gum and carbopal-934-P with the aim to study of release kinetic, to attain a near zero order release and to increase the bioavalability upto 95%. In-vitro dissolution studies were carried out using USP type 2 dissolution test apparatus. The release of drug followed a typical Higuchian...

vitamin e (α-tocopherol) is a natural antioxidant very useful for preventing the harmful effects of uv sun rays as skin aging and cancers. in this study, different mlv formulations were made using egg lecithin and varying molar ratios of α-tocopherol and/or cholesterol, and their encapsulation efficiencies were determined. the best liposomal product was incorporated into a carbomer 980 gel. the...

Strong seasonality in demand, a short product life cycle, and the absence of any price competition make the release date of first-run movies one of the main strategic decisions taken by movies’ distributors. These endogenous timing decisions, in turn, generate a strong seasonal pattern of release dates. Therefore, the observed seasonal pattern of sales is a combination of both seasonality in un...

oral ph sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (gi) as per the ph of gi, resulting in improved patient therapeutic efficacy and compliance. the ph range of fluids in various segments of the gi tract may provide environmental stimuli for drug release. the aim of this study was to design buoyant beads cont...

conclusions diclofenac-loaded nanoparticles based on properties of chitosan gelation could delay the release of drugs in the stomach and be further evaluated for the enteric delivery of diclofenac. objectives the aim of this study was to prepare and evaluate diclofenac-loaded chitosan nanoparticles based on the ionotropic gelation method. materials and methods chitosan (cs) nanoparticles contai...

hard gelatin capsule filled with acetaminophen, osmotic agent (sorbitol), a release promoter (sodium dodecyl sulfate), coated with a semipermeable cellulose acetate membrane containing a hydrophobic plasticizer (castor oil) and sealed with white bees wax plug was designed. when placed in the sink water penetrates the membrane, dissolves the osmotic agent and increases the osmotic pressure insid...

This study was performed to design bilayer floating tablets of simvastatin and lovastatin to give sustained release of simvastatin and immediate release of lovastatin. Bilayer floating tablets comprised of two layers i.e, immediate and sustained release layers. Bilayer floating tablets of simvastatin and lovastatin was formulated by using HPMCK 100M and super disintegrants like sodium alginate,...