We review below published studies of endothelium-dependent vasodilation in vivo. Endothelium-dependent vasodilation has been demonstrated in conduit arteries in vivo and in the cerebral, coronary, mesenteric, and femoral vascular beds as well as in the microcirculation of the brain and the microcirculation of cremaster muscle. The available evidence, although not complete, strongly suggests tha...

Several factors tend to create the impression that the removal of Ca from the myofibrils plays an important role in the mechanism of relaxation. Among these factors are the inhibition of the activity of the relaxing factor system of muscle by Ca (2) ; the similarity between the effect of ethylenediaminetetraacetate and the relaxing factor system in producing inhibition of myofibrillar adenosine...