background: transfusion services rely on transfusion reaction reporting to provide patient care and protect the blood supply. unnecessary discontinuation of blood is a major wastage of scarce blood, as well as man, hours and funds. the aim of the present study was to describe the main characteristics of acute transfusion reactions reported in the 4 hospital of kermanshah university of medical s...

BACKGROUND In recent years, pulmonary transfusion reactions have gained increasing importance as serious adverse transfusion events. METHODS Review of the literature. RESULTS Pulmonary transfusion reactions are not extremely rare and, according to hemovigilance data, important causes of transfusion-induced major morbidity and death. They can be classified as primary with predominant pulmona...

Transfusion-related acute lung injury (TRALI), a form of noncardiogenic pulmonary edema that develops during or within 6 h after a blood transfusion, is the most frequent cause of transfusion-associated death in the United States. Because development of TRALI is associated with donor antibodies (Abs) reactive with recipient major histocompatibility complex (MHC), a mouse model has been studied ...

Transfusion-related acute lung injury (TRALI) is one of the leading causes of death associated with transfusion of blood and blood components. The understanding of the etiology and pathophysiology of this syndrome has much improved during the last decades, nevertheless numerous issues are still unresolved and symptomatic treatment remains the cornerstone of medical management. Consequently more...

Transfusion-related acute lung injury (TRALI) constitutes a life threatening complication of blood transfusion. In severe TRALI cases supportive care with mechanical ventilation in intensive care unit is needed. We present two severe TRALI cases caused by leukocyte depleted, ABO compatible, packed red blood cell transfusions, coming from multiparous women donors. In the first case diagnosis was...

Abstract Transfusion-related acute lung injury (TRALI) is a hazardous transfusion complication with an associated mortality of 5% to 15%. We previously showed that stored (5 days) but not fresh platelets (1 day) cause TRALI via ceramide-mediated endothelial barrier dysfunction. As biological ceramides are hydrophobic, extracellular vesicles (EVs) may be required shuttle these sphingolipids from...

Background: Transfusion-related acute lung injury (TRALI) is a major cause of morbidity and mortality. The impact of HLA antibody testing on female plateletpheresis donors with four or more pregnancies was evaluated to determine if there was a reduced incidence of TRALI reported. Methods: During a 12-month period, pregnancy histories were obtained from female plateletpheresis donors. If the don...

Over the past 60 years, the transfusion medicine community has attained significant knowledge regarding transfusion-related acute lung injury (TRALI) through the bedside to bench and back to the bedside model. First, at the bedside, TRALI causes hypoxia and noncardiogenic pulmonary edema, typically within 6 hours of transfusion. Second, bedside studies showed a higher incidence in plasma and pl...