Citation: Elkord E (2016) Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans. Front. Immunol. 7:276. doi: 10.3389/fimmu.2016.00276 Helios Should not Be Cited as a marker of Human thymus-Derived tregs. Commentary: Helios+ and Helios− Cells Coexist within the natural FoXP3+...

Regulatory T cells (Tregs) participate in the negative regulation of inflammatory reactions by suppressing effector cells. In a number autoimmune disorders, suppressive function and/or Tregs is compromised. The lack active functioning can be restored with adoptive transfer expanded ex vivo autologous Tregs. our study, we traced differentiation and maturation CD4+CD25+FoxP3+CD127low over 7 days ...

OBJECTIVES A sizeable percentage of individuals infected by HIV and on antiretroviral therapy (ART) fail to increase their CD4 T-cells to satisfactory levels. The percentage of regulatory T-cells (Tregs) has been suggested to contribute to this impairment. This study aimed to address this question and to expand the analysis of Tregs subpopulations during ART. DESIGN Longitudinal follow-up of ...

Regulatory T cells (Tregs) play a critical role in immune regulation and peripheral tolerance. While different types of Tregs have been identified both mice humans, much our understanding about how these maintain homeostasis is derived from animal models. In this study, we examined two distinct human lymphoid organs to understand repeated exposure infections at the mucosal surface influences ph...

Human trials of formaldehyde-inactivated respiratory syncytial virus (FI-RSV) vaccine in 1966-1967 caused disastrous worsening of disease and death in infants during subsequent natural respiratory syncytial virus (RSV) infection. The reasons behind vaccine-induced augmentation are only partially understood, and fear of augmentation continues to hold back vaccine development. We now show that mi...

Regulatory T cells (Tregs) have a reduced capacity to activate the PI3K/Akt pathway downstream of the TCR, and the resulting low activity of Akt is necessary for their development and function. The molecular basis for the failure of Tregs to activate Akt efficiently, however, remains unknown. We show that PH-domain leucine-rich-repeat protein phosphatase (PHLPP), which dephosphorylates Akt, is ...

Foxp3(+) regulatory T cells (Tregs) maintain immune homoeostasis through mechanisms that remain incompletely defined. Here by two-photon (2P) imaging, we examine the cellular dynamics of endogenous Tregs. Tregs are identified as two non-overlapping populations in the T-zone and follicular regions of the lymph node (LN). In the T-zone, Tregs migrate more rapidly than conventional T cells (Tconv)...

Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human Considering that thick dermis contains more than thin epidermis, current understanding of might be biased toward dermal Tregs. Therefore, we sought to determine phenotype and function epidermal epithelial epidermis epithelium wer...

We examined immunological responses in patients receiving histone deacetylase (HDAC) inhibition (vorinostat) for graft-versus-host disease prophylaxis after allogeneic hematopoietic cell transplant. Vorinostat treatment increased histone acetylation in peripheral blood mononuclear cells (PBMCs) from treated patients, confirming target HDAC inhibition. HDAC inhibition reduced proinflammatory cyt...

INTRODUCTION Patients with severe combined immunodeficiency (SCID) may present with residual circulating T cells. While all cells are functionally deficient, resulting in high susceptibility to infections, only some of these cells are causing autoimmune symptoms. METHODS Here we compared T-cell functions including the number of circulating CD3(+) T cells, in vitro responses to mitogens, T-cel...