multidrug resistance (mdr) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. nevertheless, in most drug resistant cell lines and cancer patients up-regulation of abc-transporter genes such as mdr associated protein (mrp1) gene could be at the basis of the drug resistance phenotype. we aimed to decre...

ceramide as a second messenger is a key regulator in apoptosis and cytotoxicity. ceramide-metabolizing enzymes are ideal target in cancer chemo-preventive studies. neutral sphingomyelinase (nsmase), acid ceramidase (acdase) and glucosyl ceramide synthase (gcs) are the main enzymes in ceramide metabolism. silymarin flavonolignans are potent apoptosis inducers and silibinin is the most active com...

Peroxisome proliferator-activated receptors (PPARs) are nuclear and transcriptional modulators with crucial functions in hepatic whole-body energy homeostasis. Besides their well-documented roles lipid glucose metabolism, emerging evidence also implicate PPARs the control of other processes such as inflammatory responses. Recent technological advances, single-cell RNA sequencing, have allowed t...

Immunometabolism is a relatively new field of research that aims at understanding interconnections between the immune system and cellular metabolism. This now well-documented for innate cells myeloid lineage such as macrophages dendritic (DCs) when they engage their differentiation or activation programs. Several studies have shown stimulation DCs by binding pathogen-associated molecular patter...

To assess the effects of ABA deficiency on tomato fruit growth, mutant flacca was grown in an optimal soil water regime and various analyzes were performed, including morphological (fruit number, diameter biomass), physiological (duration growth rate), biochemical (ABA accumulation, enzyme cell wall peroxidase activity) as well proteomics. The analysis showed that slower rate development result...

The purpose of the present study was to investigate the context of lipid metabolism research in physical activity, lipolysis, lipolysis hormone regulation and the fate of lipolysis products in exercise, fatty acid transporters, some genes involved in lipid metabolism, effect of resistance activity on lipolysis, adaptations of adipose tissue due to physical activity, lipoproteins and apoproteins...

For several decades, it has been known that T-cell activation in vitro leads to increased glycolytic metabolism that fuels proliferation and effector function. Recently, this simple model has been complicated by the observation that different T-cell subsets differentially regulate fundamental metabolic pathways under the control of distinct molecular regulators. Although the majority of these d...