The objective of this study is to investigate the anti-tumor effect of Ginkgo biloba exocarp extracts (GBEE) on B16 melanoma bearing mice and its related molecular mechanisms. The B16-F10 melanoma solid tumor model was established in C57BL/6J mice. The tumor-bearing mice were treated with GBEE (50, 100, 200 mg/kg), taking cis-Dichlorodiamineplatinum (Ⅱ) (DDP, 3 mg/kg) as pos...

background: systemic lupus erythematosus (sle) is a multisystem autoimmune disease. emerging data suggests that t helper 17 (th17) cells play a pathogenic role in sle and the increased number of these cells correlates with disease activity. in recent years, 1α, 25-dihydroxyvitamin d3 (1,25vitd3) has been considered as an immunomodulatory factor. objective: to investigate the effect of 1,25vitd3...

objective(s): this study aims to determine the effects of ozone therapy on restoring impaired nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced ckd. materials and methods: sprague–dawley rats were fed with 0.75% adenine-containing diet to induce ckd and chronic tubulointerstitial injury. ozone therapy was administered by rectal insufflation. after 4 we...

agronomic and physiological traits and protein expression were compared between non-bt glandless upland cotton variety-zhong5629 and its bt-transgenic near-isogenic lines differing in cryiac gene. results showed that the bt isogenic line had higher plant height and rate of effective bolls, more internal bolls but lower yield, than the non-bt line. the bt isogenic line had lower chlorophyll cont...

Large forces are the primary mechanism of injury in muscular dystrophy, and muscular dystrophy is especially damaging to type IIB muscle fibers. It was hypothesized that post-tetanic potentiation (PTP) would be down-regulated to prevent damage in Xlinked muscular dystrophy (mdx) mice since PTP increases force and PTP effects are greatest in IIB fibers. PTP experiments were performed on the exte...

An inducible model for conditional expression of AML1-ETO in myeloid U-937 cells was generated previously to determine cellular effects of AML1-ETO and to identify target genes. Induction of AML1-ETO expression in U-937 resulted in reduced cell growth, G1 arrest and apoptosis. Microarray analysis showed more genes up-regulated than down-regulated (180 vs. 69). Clustering of AML1-ETO-positive an...

BACKGROUND High bone morphogenetic protein (BMP)-2 expression in lung carcinoma correlates with poor patient prognosis. The present study explored strategies to repress BMP signaling. MATERIALS AND METHODS The cytotoxicity of BMP2-knockdown, dorsomorphin derivatives, and microRNAs was tested in transformed and non-transformed lung cells. Microarray analyses of 1,145 microRNAs in A549 lung ade...