Endothelial cell dysfunction as in Fuchs dystrophy or pseudophakic bullous keratopathy, and the limited regenerative capacity of human corneal endothelial cells (HCECs), drive the need for corneal transplant. In response to limited donor corneal availability, significant effort has been directed towards cell therapy as an alternative to surgery. Stimulation of endogenous progenitors, or transpl...

Regenerative medicine is expected to be a novel therapeutic system in this century [1–3]. The human body consists of 200 cell species generated from immature stem cells. In the 1990s, a treatment transplanting hematopoietic stem cells to replace all blood cells was established and successfully cured leukemia [4]. With this as amodel, stem cell transplantation therapy is being developed to resto...

The integrity and normal function of the corneal epithelium are essential for maintaining the cornea's transparency and vision. The existence of a cell population with progenitor characteristics in the limbus maintains a dynamic of constant epithelial repair and renewal. Currently, cell-based therapies for bio-replacement, such as cultured limbal epithelial transplantation and cultured oral muc...

background and aims. the aim of this study was to evaluate the predictability of implantation at the time of maxillary and mandibular molar extraction. materials and methods. maxillary and mandibular molars were extracted with an atraumatic technique (root separation and careful extraction with a periotome) to preserve all remaining inter-radicular bone. then, 115 tapered and straight implants ...

the stem cells can be considered as the miracle of creation, because, they are a major reservoir of the bioactive factors, molecules and cells. these reservoir cells play a major role in development and growth of the tissues and organs. regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic appl...

A free radical scavenger Edaravone is the first clinical drug for neuroprotection in the world which has been used from 2001 in most ischemic stroke patients in Japan, and is especially useful in thrombolytic therapy with tissue plasminogen activator (tPA). Of great importance for regenerative therapy and gene therapy are the neural stem cells which are intrinsically activated or exogenously tr...

The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic endocrine lineages has been vigorously examined by reproducing the in vivo developmental processes of the pancreas. Recent advances in this research field have enabled the generation from hESCs/iPSCs of functionally mature β-like cells i...

Natural and synthetic biomaterials play an important role in the treatment of different diseases. Current research is trying to obtain different biomaterials with optimized characteristics. Mesenchymal stem cells with biomaterial scaffolds can provide a promising strategy for tissue engineering and cellular delivery. Because these cells are key elements of cell therapy of various diseases, eval...

The development of regenerative medicine relies in part on the capacity of stem cells to differentiate into specialized cell types and reconstitute tissues and organs. The origin of the stem cells matters. While autologous cells were initially the preferred ones the need for "off the shelf" cells is becoming prevalent. These cells will be immediately available and they originate from young non ...

The possibility of tissue rejuvenation through regenerative therapies has generated great excitement among both the scientific community and the public, especially for conditions with perceived irreversible tissue loss such as myocardial injury. Groundbreaking approaches have experimentally identified reparative capacity in the human heart, suggesting that if this process could be harnessed, th...