Neuroimaging in Migraine Metric-Based Pain Care Contemporary Physical Therapy Primary headaches represent a major burden, not only to patients but also to national health care systems in terms of socioeconomic consequences. Migraine incurs yearly costs of up to US$20 billion in the United States and up to US$27 billion in Europe. Patients with chronic primary headache have even greater impairme...

BACKGROUND Serotonin-1 5-hydroxytryptamine (5-HT 1) receptor agonists are first line agents for migraine headaches. Patients with refractory headaches may use supratherapeutic doses of these medications. Described is a case of ischemic colitis related to overuse of sumatriptan. CASE A 35-year-old woman presented with severe abdominal pain without diarrhea or hematochezia. For several days pri...

OBJECTIVES To provide updated information on the role of botulinum toxins in the treatment of refractory pain based on prospective, randomized, double-blind, placebo-controlled studies. DESIGN OF THE REVIEW: Class I and class II articles were searched online through PubMed (1966 to the end of January 2011) and OvidSP including ahead-of-print manuscripts. RESULTS Level A evidence (two or more ...

BACKGROUND Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a relatively new field of interest. The aim of the present study was to explore the clinical experience with Cefaly® in a cohort of migraine patients previously refractory or int...

BACKGROUND Refractory chronic migraine affects approximately 4% of the population worldwide and results in severe pain, lifestyle limitations, and decreased quality of life. Occipital nerve stimulation (ONS) refers to the electric stimulation of the distal branches of greater and lesser occipital nerves; the surgical technique has previously been described and has demonstrated efficacy in the t...

Abstract Background New treatments are currently offering new opportunities and challenges in clinical management research the migraine field. There is need of homogenous criteria to identify candidates for treatment escalation as well reliable refractoriness treatment. To overcome those issues, European Headache Federation (EHF) issued a Consensus document propose approach difficult-to-treat p...

UNLABELLED BACKGROUND Several studies have been conducted on managing migraine headaches and developing effective medications for decreasing migraine-associated pain. CASE PRESENTATION Intravenous propofol was prescribed (10 mg every 5 min) for eight patients with intractable migraine headaches visiting the Emergency Department. The average pain score experienced by patients was recorded u...

Cortical spreading depression (CSD) is a pathophysiological phenomenon, which underlies some neurological disorders, such as migraine and stroke, but its mechanisms are still not completely understood. One of the striking facts is that the spatiotemporal evolution of CSD wave is varying. Observations in experiments reveal that a CSD wave may propagate through the entire cortex, or just bypass s...