An intensive field measurement campaign was performed in July/August 2002 at the Global Atmospheric Watch station Izaña on Tenerife to study the interaction of mineral dust aerosol and tropospheric chemistry (MINATROC). A dense Saharan dust plume, with aerosol masses exceeding 500μg m−3, persisted for three days. During this dust event strongly reduced mixing ratios of ROx (HO2, CH3O2 and highe...

Detailed simulation of reactive flow systems using complex kinetic mechanisms consisting of hundreds of species is a computationally demanding task. In practice, to alleviate the computational complexity, the reactive flow models use a skeletal kinetic model instead of the detailed mechanism. However, the reduced chemistry models can accurately predict the detailed model only over limited range...

Detailed simulation of reactive flow systems using complex kinetic mechanisms consisting of hundreds of species is a computationally demanding task. In practice, to alleviate the computational complexity, the reactive flow models use a skeletal kinetic model instead of the detailed mechanism. However, the reduced chemistry models can accurately predict the detailed model only over a limited ran...

PROLOGUE The opioid analgesics represent an important class of agents for the treatment of severe clinical pain, but many effects often limit their usefulness. This manuscript will discuss recent findings in opioid pharmacology, and how medicinal chemists may be able to utilize these findings of novel opioid analgesics with reduced undesired effects. As such, the manuscript serves as an example...

The synthesis of adenine and thymine cyclopentylethyl nucleosides is presented. This novel constrained monomeric building block is very difficult to incorporate into oligonucleotides. It was introduced in 13mer oligodeoxynucleotide sequences at a single position using H-phosphonate chemistry. Phosphoramidite chemistry completely failed in this particular case. The H-phosphonate building blocks ...

In both lead identification and lead optimization processes there is an acute need for new organic small molecules. Traditional methods of organic synthesis are orders of magnitude too slow to satisfy the demand for these compounds. The fields of combinatorial and automated medicinal chemistry have been developed to meet the increasing requirement of new compounds for drug discovery; within the...