Inwardly rectifying K+ (IRK) channels are critical for shaping cell excitability. Whole-cell patch-clamp and single-cell RT-PCR techniques were used to characterize the inwardly rectifying K+ currents found in projection neurons of the rat nucleus accumbens. Inwardly rectifying currents were highly selective for K+ and blocked by low millimolar concentrations of Cs+ or Ba2+. In a subset of neur...

There is clear evidence that the net magnitude of negative charge at the intracellular end of inwardly rectifying potassium channels helps to generate an asymmetry in the magnitude of the current that will pass in each direction. However, a complete understanding of the physical mechanism that links these charges to current rectification has yet to be obtained. Using Brownian dynamics, we compa...

The theory of Finsler metric was introduced by Paul Finsler, in 1918. author defines this using the Minkowski norm instead inner product. Therefore, geometry is a more general and includes Riemannian metric. In present work, metric, we investigate position vector rectifying, normal osculating curves Finslerian 3-space $\mathbb{F}^{3}$. We obtain characterizations these Furthermore, show that re...

In this study, we present a bilayer resistive switching memory device with Pt/Ta2O5/HfO2-x /Hf structure, which shows sub-1 μA ultralow operating current, median switching voltage, adequate ON/OFF ratio, and simultaneously containing excellent self-rectifying characteristics. The control sample with single HfO2-x structure shows bidirectional memory switching properties with symmetrical I-V cur...

Recent experiments on symmetry-broken mesoscopic semiconductor structures have exhibited an amazing rectifying effect in the transverse current-voltage characteristics with promising prospects for future applications. We present a simple microscopic model, which takes into account the energy dependence of current-carrying modes and explains the rectifying effect by an interplay of fully quantiz...

The pharmacological activation of the cystic fibrosis gene protein cystic fibrosis transmembrane conductance regulator (CFTR) was studied in human airway epithelial Calu-3 cells, which express a high level of CFTR protein as assessed by Western blot and in vitro phosphorylation. Immunolocalization shows that CFTR is located in the apical membrane. We performed iodide efflux, whole cell patch-cl...

Membrane currents of cultured human monocytes and rat microglia were recorded with the whole-cell patch clamp technique. Freshly isolated monocytes or resting (proliferating) microglia express only inwardly rectifying K+ channels. However, incubation in teflon bags leads to the expression of additional, outwardly rectifying K+ channels. The outward K+ conductance of microglial cells was inhibit...

A rectifying curve in the Euclidean $n$-space $\mathbb{E}^n$ is defined as an arc-length parametrized $\gamma$ such that its position vector always lies space (i.e., orthogonal complement of principal normal field) $\mathbb{E}^n$. In this paper, analogy to this, we introduce notion $f$-rectifying a by $s$ $f$-position field $\gamma_f$, $\gamma_f(s) = \int f(s) d\gamma$, $\mathbb{E}^n$, where $f...

SRIF activates an inwardly rectifying K+ current in human GH-secreting adenoma cells. Activation of this K+ current induces hyperpolarization of the membrane and abolishment of action potential firing. This mechanism is an essential mechanism for SRIF-induced decrease in intracellular Ca2+ concentration and inhibition of GH secretion. The activation of the inwardly rectifying K+ current is medi...

We report a novel battery-less wireless current sensor node without an analog to digital converter (ADC). If a capacitor is charged using a current transformer (CT) and a rectifying circuit, the charging time depends on the current flowing through a power line. In the case that the node transmits data every time when voltage of the capacitor exceeds a threshold voltage, we can indirectly measur...