BACKGROUND In vitro maturation (IVM) of oocytes followed by fertilization in vitro (IVF) and embryo transfer offers an alternative to conventional IVF treatment that minimises drug administration and avoids ovarian hyperstimulation. However, the technique is less efficient than maturation in vivo. In the present study, a non-human primate model was used to address the hypothesis that the number...

hCG exists in two analogous structures, as typified by the hormone hCG which binds an LH/hCG hormone receptor and the TGFß receptor binding autocrine hyperglycosylated hCG. Both share a common α-subunit and ß-subunit amino acid sequence. From the common hormone hCG and autocrine hyperglycosylated hCG structures there are seven common hCG variants with wildly varying hormone hCG or autocrine hyp...

Abstract Study question Is patients’ BMI associated with oocyte yield and maturation following different trigger strategies r-hCG, GnRH agonist (GnRHa) or dual trigger? Summary answer Patients’ is not triggering rhCG, GnRHa trigger. What known already Triggering final a key step of ovarian stimulation for IVF/ICSI treatment. Although hCG has traditionally been the gold standard maturation, incr...

In Vitro Maturation (IVM) is a method that immature oocytes in antral follicles are extracted and matured in laboratry conditions. This review has attempted to provide the current knowledge and recent findings in in vitro maturation of oocytes and highlights the most important factors involved in this process. The review is based on literature reports and the author’s experience. In IVM cycles,...

A randomized, controlled, double-blind, double-dummy, phase III clinical trial was conducted in 84 women to compare the efficacy of a s.c. injection of 250 microg recombinant human chorionic gonadotrophin (rHCG; Ovidrel) to an i.m. injection of 5000 IU urinary HCG (uHCG; Profasi) in inducing folliculogenesis, resumption of oocyte meiosis and luteinization after ovulation induction with recombin...

BACKGROUND Home pregnancy testing devices claim >99% diagnostic accuracy for pregnancy and utility on the first day of the missed menses or earlier. We investigated the forms of human chorionic gonadotropin (hCG) in early pregnancy urines, the diagnostic accuracy claim, and the abilities of 15 devices to detect the different forms of hCG. METHODS We measured the concentrations of regular hCG ...

The onset of the spontaneous LH surge in women is relatively abrupt with concentrations doubling within 2 h to between 100 and 200 IU/l being sustained for 12–14 h over a mean duration of 50 h [1]. This mid-cycle surge, in addition to follicular rupture [2], promotes several periovulatory events including disruption of the oocyte– cumulus oophorus cell contact and induction of the resumption of...

Human choriogonadotropin (hCG) and free hCG-beta values for 934 serum samples from patients with seminomatous or nonseminomatous testicular cancer were measured by highly specific immunoradiometric assays (IRMAS). In non-seminoma samples, hCG and hCG-beta were highly correlated (r = 0.82, P less than 0.001). Of 112 "marker-positive" seminoma samples, only 46 (41.1%) showed both increased hCG an...

Preovulatory granulosa cells express the low-molecular-mass MAP2D variant of microtubule-associated protein 2 (MAP2). Activation of the luteinizing hormone choriogonadotropin receptor by human choriogonadotropin (hCG) promotes dephosphorylation of MAP2D on Thr256 and Thr259. We sought to evaluate the association of MAP2D with the cytoskeleton, and the effect of hCG on this association. MAP2D pa...