Described herein is the development of a continuous flow, solid-phase triphenylphosphine (PS-PPh3) assisted protocol to facilitate in situ coupling reciprocal pairs halogen and carbonyl functionalised molecular by Wittig olefination within 15 mins. The entails injecting single solution (1 : 1 CHCl3 EtOH) containing halogenated carbonyl-based substrates into continuously flowing stream EtOH 1), ...