Insight into the molecular basis of cholecystokinin (CCK) binding to its receptor has come from receptor mutagenesis and photoaffinity labeling studies, with both contributing to the current hypothesis that the acidic Tyr-sulfate-27 residue within the peptide is situated adjacent to basic Arg(197) in the second loop of the receptor. Here, we refine our understanding of this region of interactio...

Cannabinoid receptors (CB) are G-protein coupled receptors involved in many physiological processes, like learning, appetite, nociception and others. Two subtypes (termed CB1 and CB2) are involved in slightly different processes [1]. Thus, it is important to gain more insight into the the cannabinoid receptor system and the potential effects of cannabinoid therapeutics. By combining [2] 3D-QSAR...

In this study, methoxylated flavonoids and volatile constitutions of Agrostis gigantea Roth (Poaceae) were investigated for the first time. The flavonoids were identified by spectroscopic methods (1H-NMR, 13C-NMR, COSY, NOSEY, TCOSY, and HMBC). The volatile constitutions of aerial parts and seeds were analyzed by gas chromatography–mass spectrometry (GC-MS). Two methoxylated flavonoids, luteoli...

The present study applies the model of American Meteorological Society-Environmental Protection Agency Regulatory Model (AERMOD) to investigate NO2 emissions from Besat thermal power plant, which is fuelled by natural gas to function. Results indicate that the simulated concentration of NO2 based on AERMOD, does not exceed NO2 concentration limit, set by the Iranian Ambient Air Quality Standard...

introduction: it has been shown that administration of win55,212-2, a cannabinoid receptor agonist, into the basolateral amygdala (bla), dose-dependently increases the thermal latency to withdrawal in the tail-.ick test and decreases pain related behaviors in both phases of the formalin test. recent human and animal imaging data suggest that the nucleus accumbens (nac) is an important neural su...

This exploratory work encompasses synthetic chemistry to develop novel 3, 5- diphenylethanone derivatives compounds based on the medicinally relevant scaffold of pyrazole as that standard SERM i.e. Tamoxifen and Raloxifene. Specific strategies for synthesis analogues were used subjected modeling docking studies analyzing ER subtype selectivity. The in-silico conducted in order attain a better i...

In this study, methoxylated flavonoids and volatile constitutions of Agrostis gigantea Roth (Poaceae) were investigated for the first time. The flavonoids were identified by spectroscopic methods (1H-NMR, 13C-NMR, COSY, NOSEY, TCOSY, and HMBC). The volatile constitutions of aerial parts and seeds were analyzed by gas chromatography–mass spectrometry (GC-MS). Two methoxylated flavonoids, luteoli...

The present study applies the model of American Meteorological Society-Environmental Protection Agency Regulatory Model (AERMOD) to investigate NO2 emissions from Besat thermal power plant, which is fuelled by natural gas to function. Results indicate that the simulated concentration of NO2 based on AERMOD, does not exceed NO2 concentration limit, set by the Iranian Ambient Air Quality Standard...

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