The phenomenon of rebound effects has sparked considerable academic, policy and press debate over the effectiveness of energy efficiency policy. In recent years, a plethora of theoretical and empirical rebound studies have been published, fueling the discussion but also raising further issues and unanswered questions. At the same time, it seems that there is a lack of understanding of how to tr...

BACKGROUND AND OBJECTIVES Propranolol is first-line therapy for problematic infantile hemangiomas (IHs). Rebound growth after propranolol discontinuation is noted in 19% to 25% of patients. Predictive factors for rebound are not completely understood and may alter the management approach. The goal of the study was to describe a cohort of patients with IHs treated with propranolol and to identif...

PURPOSE To determine the incidence of rebound macular edema after intravitreal bevacizumab in eyes with macular edema secondary to branch retinal vein occlusion and to identify the pretreatment factors that were significantly associated with the rebound. METHODS The changes in the foveal thickness after the intravitreal bevacizumab (1.25 mg/0.05 mL) were studied in 65 eyes of 65 patients with...

AIMS The aims of this study were to evaluate the accuracy, repeatability, and safety of multiple intraocular pressure (IOP) measurements by a commercially available rebound tonometer in conscious, conditioned mice, and to characterize the acute and profound effects of anesthesia on IOP in mice. METHODS To test the accuracy of the tonometer, IOPs of CD-1 mice under ketamine/xylazine anesthesia...

A better understanding of fluid-related processes such as poroelastic rebound of the upper crust and weakening of the lower crust beneath the volcanic arc helps better understand and correctly interpret the heterogeneity of postseismic deformation following great subduction zone earthquakes. The postseismic deformation following the 2011 Mw9.0 Tohoku earthquake, recorded with unprecedented high...

Exposure of hippocampal slices to nitric oxide (NO) results in a depression of CA1 synaptic transmission. Under 0.2-Hz stimulation, washout of NO leads to a persistent potentiation that depends on N-methyl-D-aspartate (NMDA) receptors and endogenous NO formation and that occludes tetanus-induced long-term potentiation (LTP). The experiments were initially aimed at determining the relationship b...

Immunotherapy can paradoxically up-regulate immunosuppressive pathways, a phenomenon we term “rebound immunosuppression”. One such pathway is the immunosuppressive enzyme indolamine-2,3-dioxygenase (IDO). Here, we postulated that IDO blockade will improve immunotherapy efficacy by preventing rebound immune-suppression. It has been previously shown that immunotherapy consisting of intralesional ...

The olfactory bulb, a second-order sensory brain region, relays afferent input from olfactory receptor neurons to piriform cortex and other higher brain centers. Although large inhibitory postsynaptic potentials (IPSPs) are evident in in vivo intracellular recordings from mitral cells, the functional significance of these synaptic responses has not been defined. In many brain regions, IPSPs can...

Processes leading to an increase of demand for a resource as a consequence of increasing the efficiency of using this resource in production or consumption are known as (direct) rebound effects. Rebound effects at micro and macro levels tend to offset the reduction in resource consumption enabled by progress in efficiency. Systems thinking and modeling instruments such as causal loop diagrams a...

Sandwich-cultured human hepatocytes (SCHH) have been widely used for in vitro assessments of biliary clearance. However, the modulation of metabolism enzymes has not been fully evaluated in this system. The present study was therefore undertaken to determine the activity of cytochrome P450 (P450) 1A2, 2C8, 2C9, 2C19, 2D6, and 3A and to evaluate the impact of 1-aminobenzotriazole (ABT) on hepati...