IntroductionRET gene fusions are established oncogenic drivers in 1% of NSCLC. Accurate detection advanced patients with RET is essential to ensure optimal therapy choice. We investigated the performance fluorescence situ hybridization (FISH) as a diagnostic test for detecting functional fusions.MethodsBetween January 2016 and November 2019, total 4873 NSCLC were routinely screened using either...

The rearrangement of allyl a-bromoacetates with Zn dust is known as the Reformatsky-Claisen rearrangement. Whereas the Ireland-Claisen rearrangement has been widely used in the synthesis of a diverse range of natural products, the Zn-mediated Reformatsky-Claisen rearrangement has not been utilized so often. In this article, we will provide an overview of recent advances in the Reformatsky-Clais...

Abstract The idea of resistive switching devices is originally based on the fact that application electric fields changes atomic structure locally and thus also electronic material. This leads globally to a sustained change in resistance material layer, which generally referred as switching. In devices, these reconfigurations are reversible allow state be maintained for long time, why memristiv...

Substituted naphthofurans and naphthopyrans were constructed at high temperature from allyl or propargyl naphthyl ethers via Claisen rearrangement in moderate to good yields. Also, substituted (trimethylsilyl)-naphthofurans were synthesized from the corresponding naphtofurans.

Hydroxybenzene, commonly known as phenol, is one of the most important organic commodity chemicals. To produce cumene process used worldwide. A crucial step in this Hock rearrangement, which has a major impact on overall consumption rate and determines safety level process. The catalyst for cleavage hydroperoxide (CHP) sulfuric acid. Besides its strong corrosive property, increases plant invest...

We define a new rearrangement, called rearrangement by tamping, for non-negative measurable functions defined on R+. This has many properties in common with the well-known Schwarz non-increasing such as Pólya–Szegő inequality. Contrary to tamping also preserves homogeneous Dirichlet boundary condition of function.

Fetal mosaicism for chromosomal rearrangements remains a challenge to diagnose, even in the era of whole-genome sequencing. We present here case fetal rearrangement explored amniocytes and muscle, consisting major cell population (95%) with partial monosomy 4q minor (5%) additional material replacing 4qter deleted segment. Molecular techniques (MLPA, array-CGH) failed assess origin this materia...

Recent progress in genome-scale sequencing and comparative mapping raises new challenges in studies of genome rearrangements. Although the pairwise genome rearrangement problem is well-studied, algorithms for reconstructing rearrangement scenarios for multiple species are in great need. The previous approaches to multiple genome rearrangement problem were largely based on the breakpoint distanc...