Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC(50) = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.

A novel integrated buck-flyback non isolated power factor (PF) correction (PFC) converter is proposed in this paper. This new converter is an inherent integration of a buck converter and a flyback converter, which operates in either flyback mode or buck mode according to whether the input voltage is lower or higher than the output voltage. In this way, the dead zones of ac input current in trad...

in this paper the maximum power point tracking (mppt) algorithms for wind energy systems arereviewed. as the amounts of power produced in wind power plants is changing due to theinstantaneous changing nature of the wind, it is desirable to determine the one optimal generatorspeed that ensures maximum energy yield. thus, it is important to include a controller that cantrack the maximum peak rega...

This paper introduces a novel Bi-directional DC-DC converter with artificial neural network controller (ANN).Bidirectional power flow is obtained by the same power components and provides a simple, efficient, and galvanically isolated converter. In the presence of DC mains the converter operates as buck converter and charges the battery. When the DC main fails, the converter operates as boost c...

The retinoblastoma tumor suppressor, RB, is thought to inhibit cell cycle progression through transcriptional repression. E2F-regulated genes have been viewed as presumptive targets of RB-mediated repression. However, we found that specific E2F targets were not regulated in a consistent manner by the action of a RB allele that is refractory to cyclin-dependent kinase/cyclin-mediated phosphoryla...

Purpose: Rose Bengal (RB) is a potential photodynamic sensitizer in anticancer therapy. The purpose of this study was to prepare multivesicular liposomes (MVL) loaded with RB to enhance its photostability and intracellulaer photodynamic efficacy. Methods: Four MVL-RB formulations were prepared by reverse phase evaporation technique using a double emulsion method. The photostability of RB in pho...

Reintroduction of RB into SAOS2 (RB-/-) cells causes a G1 arrest and characteristic cellular swelling. Coexpression of the cellular transcription factor E2F-1 could overcome these effects. The ability of E2F-1 to bind to RB was neither necessary nor sufficient for this effect, and S-phase entry was not accompanied by RB hyperphosphorylation under these conditions. Furthermore, E2F-1 could overc...

Although the retinoblastoma protein (Rb) functions as a checkpoint in the cell cycle, it also regulates differentiation. It has recently been shown that Rb is acetylated during differentiation; however, the role of this modification has not been identified. Depletion of Rb levels with short hairpin RNA resulted in inhibition of human keratinocyte differentiation, delayed cell cycle exit and all...

Single-Stage transformerless AC/DC converter received much attention in the universal line application. Unlike the existing converters a new high step-down transformerless single-stage single-switch AC/DC converter is proposed. The topology integrates a buck-buck-boost converter with low intermediate bus and output voltage. The converter utilizes a buck converter as a PFC cell and buck-boost co...