In this article, by using Chebyshev’s polynomials and Chebyshev’s expansion, we obtain the best uniform polynomial approximation out of P2n to a class of rational functions of the form (ax2+c)-1 on any non symmetric interval [d,e]. Using the obtained approximation, we provide the best uniform polynomial approximation to a class of rational functions of the form (ax2+bx+c)-1 for both cases b2-4a...