HIV-1 integrase (IN) is essential for the integration of viral DNA into the host genome and an attractive therapeutic target for developing antiretroviral inhibitors. LEDGINs are a class of allosteric inhibitors targeting LEDGF/p75 binding site of HIV-1 IN. Yet, the detailed binding mode and allosteric inhibition mechanism of LEDGINs to HIV-1 IN is only partially understood, which hinders the s...

This paper describes the use of a system of semantic rules to generate noun compounds, vague or polyse-mous words, and cases of metonymy. The rules are bi-directional and are used by the understanding system to interpret the same constructions.

Let Z[i] = {a + bi : a, b ∈ Z} be the ring of Gaussian integers. All Gaussian integers will be represented by Greek letters and rational integers by ordinary Latin letters. Primes will be denoted by π and p respectively. Units will be denoted by ε = ±1,±i and 1 respectively. In 1961 Robert Spira [3] defined the sum-of-divisors function on Z[i] as follows. Let η = εΠπi i be a Gaussian integer. T...

Frequency domain identification of complex systems imposes important challenges with respect to numerically reliable algorithms. This is evidenced by the use of different rational and data-dependent basis functions in the literature. The aim of this paper is to compare these different methods and to establish new connections. This leads to two new identification algorithms. The conditioning and...

Two simple constructive methods are presented to compute compactly supported tight wavelet frames for any given refinable function whose mask satisfies the QMF or sub-QMF conditions in the multivariate setting. We use one of our constructive methods in order to find tight wavelet frames associated with multivariate box splines, e.g., bivariate box splines on a three or four directional mesh. Mo...

Our aim is to study the set of K-rational expressions describing rational series. More precisely we are concerned with the definition of quotients of this set by coarser and coarser congruences which lead to an extension – in the case of multiplicities – of some classical results stated in the Boolean case. In particular, multiplicity analogues of the well known theorems of Brzozowski and Antim...

Following an approach originally due to Mahler and sharpened by Chudnovsky, we develop an explicit version of the multi-dimensional \hy-pergeometric method" for rational and algebraic approximation to algebraic numbers. Consequently, if a; b and n are given positive integers with n 3, we show that the equation of the title possesses at most one solution in positive integers x; y. Further result...

The farmer requires detailed information on crop stress conditions in order to manage the crop growth. This information may be acquired by low granular satellite images to coarsely identify areas of interest within the field followed by ground measurements carried out by robotic surveying platforms for plant identification and segmentation. A novel concept for creating rational behaviors of sur...

Image captions are abstract expressions of content representations using text sentences, helping readers to better understand and analyse information between different media. With the advantage encoder-decoder neural networks, can provide a rational structure for tasks such as image coding caption prediction. This work introduces Convolutional Neural Network (CNN) Bidirectional Content-Adaptive...

In this paper we give two families of codes which are minimal generators of biinfmite langüages: the family of very thin codes (which contains the rational codes) and another family containing the circular codes. We propose the conjecture that ail codes are minimal generators. Résumé. Dans cet article, nous exhibons deux familles de codes qui sont générateurs minimaux du langage de mots bi-infi...