regarding the importance of sciatic nerve distribution in replacement of anal sphincter and sciatic nerve block we decided to study this matter for the first time in iran. in this way 100 cadavers (88% male and 12% female) were dissected and studied by loop microscope. the results shows that primarily, according to the first branch derived from sciatic; there would be 4 main groups. if this sam...

BACKGROUND AND OBJECTIVES Recently, administration of sciatic nerve block has been revised due to the potential benefit for postoperative analgesia and patient satisfaction after the advent of ultrasound. The aim of this study was to describe the anatomical relations of the sciatic nerve in the popliteal fossa to determine the optimal distance the needle must be positioned in order to realize t...

Protein synthesis in the nerve sheath of injured as well as intact mature and developing sciatic nerves from rat and rabbit was investigated by incubating segments of nerve with [35S]methionine in vitro. The composition of labeled proteins under the different conditions of nerve growth was analyzed by two-dimensional gel electrophoresis and fluorography. The expression of six secreted proteins ...

Functional recovery following experimental nerve injury has been notoriously difficult to quantify precisely. The current gold standard in the rat sciatic nerve model involves analysis of footprints of the recovering animal, and computation of the sciatic function index (SFI). We performed transection injuries and measured recovery both by walking track analysis and by a newer, simpler, more qu...

objectives: crocin and safranal, the major constituents of saffron, exert neuroprotective effects. in the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (stz) and confirmed by blood glu...

  Objective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation aro...

Chronic block of nerve-muscle activity is known to induce sprouting of motor nerve terminals and to enhance transmitter release at the neuromuscular junction. Increased transmitter release has been assumed to be a physiological correlate of disuse-induced sprouting of nerve terminals. We examined this assumption in the rat extensor digitorum longus muscle following chronic conduction block of t...