نتایج جستجو برای: rat ovarian granulosa cells

تعداد نتایج: 1649442  

Journal: :Journal of lipid research 2006
Salman Azhar Satyanarayana Medicherla Wen-Jun Shen Yoshio Fujioka Loren G Fong Eve Reaven Allen D Cooper

Rat ovarian granulosa rely heavily on lipoprotein-derived cholesterol for steroidogenesis, which is principally supplied by the LDL receptor- and scavenger receptor class B type I (SR-BI)-mediated pathways. In this study, we characterized the hormonal and cholesterol regulation of another member of the LDL receptor superfamily, low density lipoprotein receptor-related protein (LRP), and its rol...

2015
Chang Liu Jia Peng Martin M. Matzuk Humphrey H-C Yao

Organogenesis of the ovary is a highly orchestrated process involving multiple lineage determination of ovarian surface epithelium, granulosa cells and theca cells. Although the sources of ovarian surface epithelium and granulosa cells are known, the origin(s) of theca progenitor cells have not been definitively identified. Here we show that theca cells derive from two sources: Wt1(+) cells ind...

Journal: :The Journal of clinical endocrinology and metabolism 2000
M P Laitinen M Anttonen I Ketola D B Wilson O Ritvos R Butzow M Heikinheimo

Previous studies have implicated transcription factors GATA-4 and GATA-6 in the regulation of murine ovarian development and function. In rodents, GATA-4 is expressed in granulosa cells of primary and early antral follicles, whereas GATA-6 is expressed in granulosa cells of late antral follicles and luteal glands. Both transcription factors can be detected in lesser amounts in theca cells and i...

Journal: :Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2000
E K Asem S Feng S R Stingley-Salazar J J Turek A T Peter J P Robinson

Experiments were conducted to determine the influence of basal lamina on the morphology of ovarian granulosa cells in vitro. Pure and intact basal lamina was isolated from the large preovulatory follicles of the chicken ovary and designated basal lamina of avian ovarian follicle (BLAOF). Examination of the isolated basal lamina with electron microscope revealed an ultrastructure that is similar...

A. Ahangarpoor M. Hashemitabar M. Mesbah N. Erfani Majd N. Salamat,

  To study viability and activity of isolated common carp, Cyprinus carpio, ovarian follicular cells (granulosa and theca cells), 17- α -Hydroxy progesterone (17 α -OHP) and 17 β -Estradiol (E2) levels were estimated in the culture media of cultivated carp ovarian follicular cells, using radioimmunoassay (RIA). Oocytes were isolated from the ovaries of female carp. Interstitial tissue was manua...

Journal: :The Journal of biological chemistry 2004
Satoko Sudo Orna Avsian-Kretchmer Lora Shuo Wang Aaron J W Hsueh

Bone morphogenetic proteins (BMPs) are important for body patterning and morphogenesis, whereas several BMP antagonists regulate the functions of BMPs during embryonic development and tissue differentiation. Protein related to DAN and cerberus (PRDC) is a secreted protein with a cystine knot structure identified by gene trapping in embryonic stem cells. Although PRDC shows sequence homology wit...

2012
Danielle M. Maatouk Lindsey Mork Ashley Hinson Akio Kobayashi Andrew P. McMahon Blanche Capel

The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and direct testis or ovary development. It is well established that germ cells are not required for the establishment or maintenance of Sertoli cells or testis cords in the male ...

2016
Yang Gao David F. Vincent Anna Jane Davis Owen J. Sansom Laurent Bartholin Qinglei Li

Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage. To define the role of TGFβ signaling in ovarian tumorigenesis, we created a mouse model expressing a constitutively active TGFβ receptor 1 (TGFBR1) in ovarian somatic cells using conditional gain-of-function approach. Remarkably,...

Journal: :Acta biochimica et biophysica Sinica 2013
Juan Zhang Hui Li Zhao Wu Xiaojun Tan Fengying Liu Xianghong Huang Xiaoling Fang

Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles before 40 years of age, representing one major cause of female infertility. Stem cells provide the possibility of a potential treatment for POF. In this study, rat embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) were co-cultured with granulosa cells (GCs) to ...

Journal: :Human reproduction 1998
W M Enien E Chantler M W Seif M Elstein

The study investigates the correlation between oocyte maturity and fertilization and a variety of hormonal parameters in follicular fluid and ovarian granulosa cells. A methodology for purification of granulosa cells from contaminating blood cells is also established. A total of 63 follicular aspirates were collected at oocyte retrieval from 30 women superovulated using the long luteinizing hor...

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