A comparative study of the transport of pyruvate in mitochondria isolated from normal rat liver and from three tumors has been carried out. The Km for net pyruvate uptake in mitochondria isolated from Ehrlich ascites tumor cells is practically equal to that measured in normal rat liver mitochondria while, on the other hand, it is higher in Morris hepatomas 44 and 3924A. The Vmax of pyruvate upt...

A high rate of aerobic glycolysis was catalyzed by rat-1 cells transfected with a ras oncogene (ras cells); rat-1 cells and rat-1 cells transfected with myc oncogene (myc cells) showed a low rate of glycolysis that was increased after exposure of the cells to type B transforming growth factor (TGF-beta). The uptake of radioactive methylaminoisobutyric acid or L-methionine via system A of amino ...

A comparative study of the transport of pyruvate in mitochon dria isolated from normal rat liver and from three tumors has been carried out. The Kmfor net pyruvate uptake in mitochondria isolated from Ehrlich ascites tumor cells is practically equal to that measured in normal rat liver mitochondria while, on the other hand, it is higher in Morris hepatomas 44 and 3924A. The Vm» of pyruvate upt...

Since its development in the 1970's, whole embryo culture (WEC) has provided an important method of growing and observing murine embryos ex utero. During WEC, embryos are immersed in a combination of rat serum and cell culture media, and supplied with heat and appropriate mixtures of CO₂ and oxygen that mimic growth conditions in utero. One significant factor limiting the widespread use of WEC ...

In this paper a standardized reproducible technic for obtaining non-necrotic transplantable tumors of uniform size and growth rate will be described, and the principal factors contributing to variability in growth rate will be analyzed. A number of potential objections have been raised to the extrapolation of results obtained with trans plantable tumors to tumors of spontaneous origin (e.g., ex...

this paper establishes new support for implementing outward oriented trade policies by relating industrial sector growth, trade policy orientation and export growth in 36 developing countries,including iran using a logistic growth function. based on thisstudy the use of stronglyoutward oriented policies towards export is likly relatedto a faster growth ofthe share of industrial output in gdp as...

Sex of day-12 rat embryos was determined using Barr body counts made on spreads of amniotic membranes examined histologically. Embryonic weight, protein content and rate of thymidine incorporation were compared in male and female embryos. Male embryos were found to be heavier and accordingly to contain more protein on absolute but not on per unit weight basis. The rate of thymidine incorporatio...

A CONSIDERABLE amount of work has been done on the growth and regeneration of the adult mammal liver and theories of liver growth control have been put forward, the most far-reaching of which was advanced by Glinos (1958). According to this theory, the growth of the liver is regulated by a feed-back mechanism, involving diffusible chemical substances secreted into the blood by the liver itself....

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increased in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correlates with cell motility of Dunning prostate cancer cell lines and accurately distinguishes cell lines with high metastatic potential from those with low metastatic potential. Increased GA...