Cataract and retinopathy remain the preventable cause of blindness worldwide, many pharmacological strategies have been proposed for treatment these eye diseases. Animal models play an important role in understanding pathophysiological features disease developing a new therapy. In this study, we investigated development cataract retinal lesion with diabetes using obese type 2 diabetic SDT fatty...

The Fischer 344 x Brown Norway (F344xBN) rat has been demonstrated to have a lower incidence of age-related pathology than other rat strains. Therefore, to elucidate the effects of aging on cardiac function, uncomplicated by compensatory effects caused by age-related pathology, cardiac myocytes were isolated from female F344xBN rats at 6 (young) and 32-33 (old) mo of age. Myocytes showed an inc...

The age-associated alteration in expression levels of carboxylesterases (CESs) can affect both intestinal and hepatic first-pass metabolism after oral administration of xenobiotic esters such as prodrugs. In this study, the age-related expression of CES isozymes and hydrolase activities were simultaneously investigated in liver, jejunum, and ileum from 8-, 46-, and 90-week-old rats. Rat liver e...

The aim of the study was to evaluate morphological features nNOS-positive (nNOS-IR) neurons in dorsolateral cortex frontal lobe cerebral hemispheres albino rats during 180 days postnatal development. Material and methods . performed on 40 outbred white Wistar different ages, from 1 days. object an area right hemisphere surface near pole (neocortex). On paraffin serial sections lobe, immunohisto...