INTRODUCTION Randomized controlled trials provide the best method of determining which of two comparable treatments is preferable. Unfortunately, contemporary randomized trials have become increasingly expensive, complex and burdened by regulation, so much so that many trials are of doubtful feasibility. DISCUSSION Here we present a proposal for a novel, streamlined approach to randomized tri...

Effectiveness of painting art therapy on fatigue children with cancer undergoing chemotherapy: A randomized trial

Evening Primrose versus Misoprostol for Cervical Dilatation before Gynecologic Surgeries; a Double–blind Randomized Clinical Trial

OBJECTIVE To compare the effects on back pain of teriparatide versus alendronate, we analyzed the reporting of back pain in a head to head comparator trial and a followup study. METHODS In the comparator trial, women were randomized to receive either daily self-injected teriparatide 40 microg plus an oral placebo (n = 73), or daily oral alendronate 10 mg plus self-injected placebo (n = 73). T...

Background: Among manuscripts submitted to biomedical journals, randomized controlled trials (RCTs) form the backbone of evidence-based medicine. Hence, their protocol should be designed rigorously and their results should be reported clearly. To improve the quality of RCT reporting, researchers developed the CONSORT Statement in 1996 and updated it in 2010. This study was designed to assess th...