Background and aim: Pigmented purpuric dermatoses are a group of chronic and recurrent skin diseases resulting from lymphocyte-mediated leakage of erythrocytes. No effective treatment has been suggested for these conditions. This study was performed to evaluate the efficacy of oral pentoxiphylline in the treatment of pigmented purpuric dermatoses.Materials and Methods: ...

BACKGROUND Despite sparse pediatric data on effectiveness, the majority of critically ill children receive medications to prevent gastrointestinal (GI) bleeding. Stress ulcer prophylaxis may have unintended consequences-increasing the risk of nosocomial infections-which may be more serious and common than the bleeding which these drugs are prescribed to prevent. Randomized controlled trials (RC...

BACKGROUND Elective single embryo transfer (eSET) in a selected group of patients (i.e. young patients with at least one good quality embryo) reduces the number of multiple pregnancies in an IVF programme. However, the reduced overall multiple pregnancy rate (PR) is still unacceptably high. Therefore, a randomized controlled trial (RCT) was conducted comparing eSET and double embryo transfer (D...

to identify the antidiabetic plants of iran, a systematic review of the published literature on the efficacy of iranian medicinal plant for glucose control in patients with type 2 diabetes mellitus was conducted. we performed an electronic literature search of medline, science direct, scopus, proquest, ebsco, googlescholar, sid, cochrane library database, from 1966 up to june 2010. the search t...

BACKGROUND AND AIMS Psychiatric or substance use disorders are barriers to successful HCV antiviral treatment. In a randomized, controlled trial (RCT), the effects of HCV Integrated Care (IC) for increasing treatment rates and sustained viral response (SVR) were studied with direct acting antivirals (DAA). METHODS In 2012-13, VA patients, whose screening was positive for depression, PTSD, or ...

BACKGROUND Since the introduction of randomized controlled trials (RCT) in clinical research, there has been discussion of whether enrolled patients have worse or better outcomes than comparable non-participants. OBJECTIVE To investigate whether very preterm infants randomized to a placebo group in an RCT have equivalent neurodevelopmental outcomes to infants who were eligible but not randomi...

BACKGROUND Cost-effectiveness analyses (CEAs) that use patient-specific data from a randomized controlled trial (RCT) are popular, yet such CEAs are criticized because they neglect to incorporate evidence external to the trial. A popular method for quantifying uncertainty in a RCT-based CEA is the bootstrap. The objective of the present study was to further expand the bootstrap method of RCT-ba...

BACKGROUND Factors influencing patients' motivations for enrolling in, and their experiences of, orthopaedic randomized controlled trials (RCTs) are not fully understood. Less is known about healthcare professionals' (HCP) experiences of RCT involvement. AIM This study investigates patients' and HCPs' views and experiences of RCT participation and delivery to inform the planning of future RCT...

Introduction: Couples at high risk of transmitting a genetic disease to their offspring have several reproductive options. As decision making is often experienced as difficult, there need for aid (DA), assist couples in decision-making process and reduce decisional conflict increase (joint) informed decision-making. This article describes the design nationwide randomized controlled trial assess...