Physical exercise would improve postural stability, which is an essential factor in preventing accidental fall among the elderly population. The aim of this study is to examine the effectiveness of treadmill walking on balance improvement among the elderly people. A total of 30 community dwelling older adults with a Berg Balance Scale score of 36-48 and the ability to walk without aid were cons...

Given the increase in novel agents and difficulty with planning and completing many phase III studies, various phase II trial design options should be considered to more effectively guide phase III trial plans. The need for novel phase II trial designs has increased, given the number of novel molecular targeted therapies now available for testing, an abundance of cytostatic agents, and limited ...

This is a report of a cluster randomized clinical trial evaluating the effectiveness of a church-based educational intervention aimed at improving African Americans' (AA) participation in clinical trials. Two hundred and twenty-one AA subjects ages ≥50 years from six predominantly AA churches were randomized to intervention or control condition. The intervention included three educational sessi...

lamotrigine has been used widely in the treatment of partial and secondary generalized seizures. in this study use of lamotrigine as monotherapy for the newly diagnosed primary generalized tonic–clonic seizure has been investigated and compared with carbamazepine. after dose escalation (3 weeks for carbamazepine and 6 weeks for lamotrigin), patients were followed every 4 weeks for the first 16 ...

a recent randomized clinical trial showed buspirone efficacy in the treatment of attention-deficit/hyperactivity disorder (adhd) in children. however, results from a recent multi-site controlled clinical trial of transdermal buspirone failed to separate it from placebo in a large sample of children with adhd. therefore, due to these inconsistent findings, this study was designed to assess the e...

background irritable bowel syndrome (ibs) is one of the common gastrointestinal disorders with unknown etiology. in experimental models, it is proposed that soy isoflavones may suppress the clinical and psychological symptoms of ibs by alteration of gut barrier tight junctions. methods we conducted this study to evaluate the effects of soy isoflavones on ibs symptoms and patients’ quality of li...

background corticosteroids are used to induce remission in auto-immune hepatitis. they are not universally effective; therefore, alternative treatments are needed. in this study cysclosporine-a has been compared with prednisolone as an alternative treatment in a randomized controlled trial. this paper is an interim analysis of an ongoing clinical trial. methods sixteen years and older consentin...

background: oral health education for the mothers of very young children is important in reducing the risk of early childhood caries. this study aimed to evaluate the impact of an oral health intervention among mothers of 1-2 years old children. methods: this cluster randomized controlled trial (2012) was conducted among ninety mothers of 1-2 year old children. the setting of study was 10 child...

Considerable intellectual and practical effort has been expended on designing and evaluating placebo controls in acupuncture studies. Somewhat less attention has been paid to the question: Why use a placebo in a randomized trial of acupuncture? This is partly because placebo controls have generally been seen as an inherent part of randomized trial methodology. As a result, most acupuncture tria...

background: diabetes mellitus) type 2) is an important health problem throughout the world. this study aimed at evaluat ing the effect of a designed educational program on the lifestyle of the patients suffering from type 2 diabetes mellitus. methods: ninety eligible diabetic patients aged 30-60 years old were recruited and then willingly assigned to two groups of clinic group (n= 45) who recei...