BACKGROUND Factors influencing patients' motivations for enrolling in, and their experiences of, orthopaedic randomized controlled trials (RCTs) are not fully understood. Less is known about healthcare professionals' (HCP) experiences of RCT involvement. AIM This study investigates patients' and HCPs' views and experiences of RCT participation and delivery to inform the planning of future RCT...

Purpose As breast cancer survivors (BCS) increasingly use complementary and alternative medicine, randomized controlled trials (RCT) are needed to assess the safety and efficacy of these therapies to guide appropriate clinical use. However, many RCTs face poor patient accrual, especially among populations at risk for health disparities. The purpose of this study is to quantify the barriers to p...

CareToy system is an innovative tele-rehabilitative tool, useful in providing intensive, individualized, home-based, family-centred Early Intervention (EI) in infants. Our aim was to evaluate, through a Randomized Clinical Trial (RCT) study, the effects of CareToy intervention on early motor and visual development in preterm infants. 41 preterm infants (range age: 3.0-5.9 months of corrected ag...

Background Low-intensity self-guided mental health interventions that are delivered on the web may meet needs and preferences of adults with mild to moderate symptoms. However, few clinical trials have examined effectiveness transdiagnostic within a naturalistic setting. Objective This randomized controlled trial (RCT) tests video-based intervention FitMindKit in reducing depression symptoms (p...

BACKGROUND Adequate nutrition of critically ill patients plays a key role in the modulation of metabolic response to stress. OBJECTIVE This paper presents the development of a protocol for a randomized controlled trial (RCT) aimed at comparing clinical outcomes of patients in the intensive care unit (ICU) administered with standard and protein-fortified diet. Together with the RCT study proto...

Acupuncture is widely used in China for various conditions. Recently, due to the limitations of conventional treatment, many patients with psychogenic erectile dysfunction (ED) tend choose acupuncture therapy, which more commonly applied countries such as China. The present clinical trial protocol aimed initially verify efficacy and safety treatment ED. Our study a prospective, randomized contr...

OBJECTIVE The conduct of underpowered randomized controlled trials (RCT) has recently been criticized in medical journals. We investigated the current prevalence of underpowered RCT in rheumatology. METHODS We searched to identify randomized, prospective RCT assessing clinical efficacy of treatments for adult rheumatic diseases published in English in 2001 and 2002. RCT were assessed as posit...

Objective: This chapter serves as a narrative review of the randomized controlled trial (RCT) evidence demonstrating reduction in lung cancer mortality with low-dose computed tomography (LDCT) and interaction aspects that contribute to an effective screening program.

BACKGROUND Patients, now generally well informed through dedicated websites and support organizations, are beginning to look askance at clinical experimentation. We conducted a survey investigation to verify whether women with endometriosis would still accept to participate in a randomized controlled trial (RCT) on treatment for pelvic pain. METHODS A total of 500 patients consecutively self-...

Limitations of the NOAC randomized controlled trial (RCT) evidence base The multinational NOAC RCTs demonstrated noninferiority to warfarin at and below the following mean international normalized ratio (INR) time in therapeutic range (TTR): 64% for dabigatran in the RELY (Randomized Evaluation of Long-term Anticoagulation Therapy) trial ; 55% for rivaroxaban in the Rocket-AF (Rivaroxaban Once ...