this randomized clinical trial aimed to assess the efficacy of phlebotomy on improvement of hearing loss. 71 patients with sudden sensorineural hearing loss were enrolled in this randomized clinical trial study. they were divided into two groups: group a received steroid and hydration therapy plus phlebotomy, while group b received the same regimen without phlebotomy. they were matched accordin...

UNLABELLED BACKGROUND All randomized clinical trials (RCTs) require a protocol; however, numerous studies have highlighted protocol deficiencies. Reporting guidelines may improve the content of research reports and, if developed using robust methods, may increase the utility of reports to stakeholders. The objective of this study was to systematically identify and review RCT protocol guideli...

The objective of this review is to assess the clinical evidence for or against acupressure as a treatment for neurological disorders. We searched the literature from 12 databases from their inception to July 2010. We included any type of controlled clinical trial (CCT) in which patients with neurological disorders were treated with acupressure. The methodological quality of all clinical trials ...

BACKGROUND Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant results and whether the proportion of trials with significant results differs ...

Advances in information technology and near ubiquity of the Internet have spawned novel modes of communication and unprecedented insights into human behavior via the digital footprint. Health behavior randomized controlled trials (RCTs), especially technology-based, can leverage these advances to improve the overall clinical trials management process and benefit from improvements at every stage...

Variance estimators are derived for estimators of the average lead time and average benefit time due to screening in a randomized screening trial via influence functions. The influence functions demonstrate that these estimators are asymptotically equivalent to the mean difference, between the study and control case groups, in the survival times. For estimating benefit time, the survival time i...

Most discrete-event simulation models have stochastic elements that mimic the probabilistic nature of the system under consideration. A close match between the input model and the true underlying probabilistic mechanism associated with the system is required for successful input modeling. The general question considered here is how to model an element (e.g., arrival process, service times) in a...

background: hydroxymethylglutaryl‑coenzyme a reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events. the purpose of this study was to determine the effect of simvastatin on serum vitamin d status in dyslipidemic patients as vitamin d status has an impact on mo...

conclusions barberry supplementation reduces oxidative burden in patients with metabolic syndrome. results there was no significant difference between the groups regarding their baseline pab values (p = 0.32). a significant decrease in pab was observed in the barberry group (p = 0.022), whilst there was no significant change in the control group (p = 0.18). the magnitude of change in pab during...