Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanopart...

A controllable self-Raman laser using an adaptive optics (AO)-based control loop featuring an intracavity deformable mirror is reported. This method has the potential to alleviate thermal lensing within the Raman and laser gain media, and enable solid-state Raman lasers to reach new power levels. A proof-of-concept experiment using a Nd:YVO4 self-Raman laser and resulting in 18% enhancement of ...

Single bacterial spores were analyzed by using nonlinear Raman microspectroscopy based on coherent anti-Stokes Raman scattering (CARS). The Raman spectra were retrieved from CARS spectra and found to be in excellent agreement with conventionally collected Raman spectra. The phase retrieval method based on maximum entropy model revealed significant robustness to external noise. The direct compar...

We investigated the performance of RAMAN-EDFA, RAMAN-SOA, EDFA-SOA hybrid Amplifiers in 120 channel WDM systems with each channel having data rate 10 Gbps at reduced channel spacing of 50 GHz. The performance has been compared on the basis of different fiber length at dispersion equal to 2 ps/nm/km in terms of Qfactor, BER and Eye opening. The results showed that RAMAN – EDFA provides the highe...

UV Raman spectroscopy is a powerful tool for investigating the structures and interactions of the aromatic side chains of Phe, Tyr, Trp, and His in proteins. This is because Raman bands of aromatic ring vibrations are selectively enhanced with UV excitation, and intensities and wavenumbers of Raman bands sensitively reflect structures and interactions. Interpretation of protein Raman spectra ...

Currently, positive endoscopic biopsy is the standard criterion for gastric cancer diagnosis but is invasive, often inconsistent, and delayed although early detection and early treatment is the most important policy. Raman spectroscopy is a spectroscopic technique based on inelastic scattering of monochromatic light. Raman spectrum represents molecular composition of the interrogated volume pro...

Fluorescence and Raman bimodal imaging and Raman multifrequency imaging of Hela cells are carried out with the help of two kinds of graphene oxide-based hybrids. As a multifunctional platform, graphene oxide acts as not only a Raman probe, but also as a substrate for Raman and fluorescent probes to load on.

Raman spectroscopy is a unique optical technique that can probe the changes of vibrational modes of biomolecules associated with tissue premalignant transformation. This study evaluates the clinical utility of confocal Raman spectroscopy over near-infrared (NIR) autofluorescence (AF) spectroscopy and composite NIR AF/Raman spectroscopy for improving early diagnosis of cervical precancer in vivo...

Maxwellite NaFe(3+)(AsO4)F is an arsenate mineral containing fluoride and forms a continuous series with tilasite CaMg(AsO4)F. Both maxwellite and tilasite form a continuous series with durangite NaAl(3+)(AsO4)F. We have used the combination of scanning electron microscopy with EDS and vibrational spectroscopy to chemically analyse the mineral maxwellite and make an assessment of the molecular ...