OBJECTIVE Loss-of-function mutations in Perk (EIF2AK3) result in permanent neonatal diabetes in humans (Wolcott-Rallison Syndrome) and mice. Previously, we found that diabetes associated with Perk deficiency resulted from insufficient proliferation of beta-cells and from defects in insulin secretion. A substantial fraction of PERK-deficient beta-cells display a highly abnormal cellular phenotyp...

The problem of pure thermovibrational flow in a two-dimensional square cavity containing viscoelastic liquid is investigated the framework numerical approach based on governing balance equations for mass, momentum, and energy their complete non-linear time-dependent form. For closure, these are complemented with transport equation elastic stress formulated using finitely extensible nonlinear Ch...

The present study aims to probe the role of an influential factor heretofore scarcely considered in earlier studies field thermovibrational convection, that is, specific time-varying shape forcing used produce fluid motion under effect imposed temperature gradient. Towards this end, two different temporal profiles acceleration are considered: a classical (sinusoidal) and pulse (square) wave. Th...

1. Jacobs E, Chen AH, Karliner LS, Agger-Gupta N, Mutha S. The need for more research on language barriers in health care: a proposed research agenda. Milbank Q 2006; 84: 111–3. 2. John-Baptiste A, Naglie G, Tomlinson G et al The effect of English language proficiency on length of stay and in-hospital mortality. J Gen Intern Med 2004; 19: 221–8. 3. Bhandari VK, Wang F, Bindman AB, Schillinger D...

EDITOR—Silver-Russell syndrome (SRS) describes a uniform malformation syndrome characterised by intrauterine and postnatal growth retardation (IUGR/PGR), asymmetry of the head and limbs, a small triangular face, and other less constant features. The majority of the 400 cases described so far occurred sporadically, but some familial cases indicate a genetic cause of the disease. In rare cases, c...

FOR THE PAST 100 yr or so, the Flexner 2 2 model of medical education has been the dominant paradigm for undergraduate medical curricula (4). The recognition of disadvantages with this approach has prompted a growing movement of curricular reform, beginning with a focus on pedagogical format and, more recently, resulting in the transition to integrated curricula designed to foster a stronger co...

OBJECTIVE To provide an overview of the course of systemic lupus erythematosus (SLE) following the onset of end-stage lupus nephropathy, regarding clinical and serological manifestations, survival on dialysis, and renal transplant outcomes. METHODS A review of the pertinent literature, identified by a comprehensive Grateful Med search, was performed. RESULTS There is a tendency for decrease...