Ionizing radiation-induced pulmonary injury is a major limitation of radiotherapy for thoracic tumors. We have demonstrated that triptolide (TPL) could alleviate IR-induced pneumonia and pulmonary fibrosis. In this study, we explored the underlying mechanism by which TPL mitigates the effects of radiotoxicity. The results showed that:(1) Alveolar macrophages (AMs) were the primary inflammatory ...

Radiation therapy (RT) is one of the highly effective treatments option for clinically advanced tumor, and plays a prominent role in cancer therapy and prognosis. It is estimated that 62% of newly diagnosed cancer patients are treated with radiation therapy [1]. The efficacious radiation therapy depends upon the homogenous delivery of total dose which could eliminate tumor cells while protectin...

BACKGROUND The alpha-emitter 223Ra, which localizes in osteoblastic active zones, including on skeletal surfaces and in osteoblastic metastases, has recently been introduced as a potential therapeutic agent against skeletal metastases. Here, the adverse effects of high dosages in animals were investigated. MATERIALS AND METHODS Balb/c mice received intravenously (i.v.) either 1250, 2500, or 3...

BACKGROUND Biomarkers are needed to individualize cancer radiation treatment. Therefore, we have investigated the association between various risk factors, including single nucleotide polymorphisms (SNPs) in candidate genes and late complications to radiotherapy in our nasopharyngeal cancer patients. METHODS A cohort of 155 patients was included. Normal tissue fibrosis was scored using RTOG/E...

The application of boron neutron capture therapy (BNCT) mediated by liposomes containing (10)B-enriched polyhedral borane and carborane derivatives for the treatment of head and neck cancer in the hamster cheek pouch oral cancer model is presented. These liposomes are composed of an equimolar ratio of cholesterol and 1,2-distearoyl-sn-glycero-3-phosphocholine, incorporating K[nido-7-CH3(CH2)15-...

Zirconia-Magnesia Inert Matrix Fuel and Waste Form: Synthesis, Characterization and Chemical Performance in an Advanced Fuel Cycle by Kiel Steven Holliday Dr. Ken Czerwinski, Examination Committee Chair Professor of Chemistry Chair of the Department of Radiochemistry University of Nevada, Las Vegas There is a significant buildup in plutonium stockpiles throughout the world, because of spent nuc...

Plasminogen activator inhibitor type 1 (PAI-1) and protease-activated receptor-1 (PAR-1) are crucial mediators of the intestinal microenvironment and are involved in radiation-induced acute and chronic injury. To evaluate whether genetic polymorphisms of PAI-1 and PAR-1 were predictors of radiation-induced injury in patients with rectal cancer, we retrospectively evaluated 356 rectal cancer pat...

BACKGROUND Both Gamma-Knife radiosurgery (GKRS) and BRAF inhibitors (BRAF-I) have been shown to be useful in melanoma patients with brain metastases (BMs), thus suggesting that it could be interesting to combine their respective advantages. However, cases of radiosensitization following conventional radiation therapy in BRAF-I treated patients have raised serious concerns about the real feasibi...