squamous cell carcinoma (scc) is the most common malignancy of the oral cavity. this study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.the authors searched all electronic databases (medline, embase and cochrane) for all the articles published from 1970 to janua...

PURPOSE Radiation pneumonitis (RP) has been a challenging obstacle in treating stage III lung cancer patients. Beam angle optimization (BAO) technique for Tomotherapy was developed to reduce the normal lung dose for stage III non-small cell lung cancer (NSCLC). Comparative analyses on plan quality by 3 different Intensity-modulated radiation therapy (IMRT) methods with BAO were done. MATERIAL...

Purpose: In the current study, using different radiobiological models, tumor control probability (TCP) and normal tissue complication probability (NTCP) of radiotherapy plans were calculated for three-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) of prostate cancer.Methods and Materials: 10 prostate plans were randomly selected among patients ...

In this work we present a novel treatment planning technique called interactive dose shaping (IDS) to be employed for the optimization of intensity modulated radiation therapy (IMRT). IDS does not rely on a Newton-based optimization algorithm which is driven by an objective function formed of dose volume constraints on pre-segmented volumes of interest (VOIs). Our new planning technique allows ...

Understanding head scatter characteristics of photon beams is vital to properly commission treatment planning (TP) algorithms. Simultaneously, having definitive surface and buildup region dosimetry is important to optimize bolus. The Elekta Precise linacs have unique beam flattening filter configurations for each photon beam (6, 10, and 18 MV) in terms of material and location. We performed a c...

The feasibility of using dual bias metal oxide semiconductor field effect transistors (MOSFET) detectors with the new hemispherical brass build up cap for in vivo dose measurements in Prostate IMRT treatments was investigated and achieved. A general formalism with various correction factors taken into account to predict Dmax entrance skin dose for the IMRT fields with MOSFETS was developed and ...

A method to verify the monitor units for a treatment plan is to calculate point doses, possibly at the isocentre, by using a simple calculation method. This verification is recommended to find mistakes in the treatment plan. Treatment plans for intensity modulated radiation therapy are no exception. The method should employ a simple physical model and a dose calculation algorithm, which is diff...

Direct aperture optimization (DAO) has been used to produce high dosimetric quality intensity-modulated radiotherapy (IMRT) treatment plans with fast treatment delivery by directly modeling the multileaf collimator segment shapes and weights. To improve plan quality and reduce treatment time for our in-house treatment planning system, we implemented a new DAO approach without using a global obj...

Radiation therapy is an important modality in treating various cancers. Various treatment planning and delivery technologies have emerged to support intensity modulated radiation therapy (IMRT), creating significant opportunities to advance this type of treatment. However, one of the fundamental questions in treatment planning and optimization, 'can we produce better treatment plans relying on ...

BACKGROUND In order to benefit from the highly conformal irradiation of tumors in ion radiotherapy, sophisticated treatment planning and simulation are required. The purpose of this study was to investigate the potential of MRI for ion radiotherapy treatment plan simulation and adaptation using a classification-based approach. METHODS Firstly, a voxelwise tissue classification was applied to ...