Lung cancer, which can be classified into nonsmall cell lung cancer (NSCLC) and small cell lung cancer (SCLC), is the leading cause of cancerrelated death in the world. NSCLC, which accounts for 80 to 85% of all lung cancers, is distinguished from SCLC by its clinical course and its response to chemotherapy and radiotherapy. More than 70% of NSCLC patients present with unresectable locally adva...

The purpose of this study was to evaluate the capabilities of DMLC to deliver the respiratory motion-synchronized dynamic IMRT (MS-IMRT) treatments under various dose rates. In order to create MS-IMRT plans, the DMLC leaf motions in dynamic IMRT plans of eight lung patients were synchronized with the respiratory motion of breathing period 4 sec and amplitude 2 cm (peak to peak) using an in-hous...

Over the past few years several automatic and semi-automatic PET segmentation methods for target volume definition in radiotherapy have been proposed. The objective of this study is to compare different methods in terms of dosimetry. For such a comparison, a gold standard is needed. For this purpose, realistic GATE-simulated PET images were used. Three lung cases and three H&N cases were design...

background: inflammatory myofibroblastic tumor (imt) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. the most common sites of involvement include the lung, liver and orbit, but it has been reported to occur in nearly every site of the body, including oral cavity and soft tissue. although common in other sites, such a tumo...

The aim of this study was to investigate the relationship between standardized uptake value (SUV), obtained from [18F]fluorodeoxyglucose positron emission tomography (FDG PET), and treatment response and survival of inoperable NSCLC patients treated with high dose radiotherapy. Fifty-one patients were included, recording stage, performance, weight loss, tumour volume, histology, lymph node invo...

leiomyosarcoma is a rare entity in prostate but it is the most common type of prostate sarcomas in adult patients. in most reported series the prognosis is poor and the median survival is about 15-18 months. hereby we present a 72 years old man who received combined modality treatment including radical surgery followed by adjuvant chemotherapy and radiotherapy. he has been well for 14 months, b...

BACKGROUND Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhibitor that overcomes Crizotinib resistance. Radiotherapy is an integral therapeutic component of locally advanced lung cancer. Therefore, we sought to investigate the effects of...

AIMS AND BACKGROUND Radiation-induced lung toxicity occurs frequently in patients with esophageal carcinoma. This study aims to evaluate the clinical and three-dimensional dosimetric parameters associated with lung toxicity after radiotherapy for esophageal carcinoma. METHODS AND STUDY DESIGN The records of 56 patients treated for esophageal carcinoma were reviewed. The Radiation Therapy Onco...

Introduction: In radiation therapy of lung tumors, respiratory motion causes target moving, so a larger margin is needed to cover the clinical target volume (CTV). With the margin increasing, a larger volume of normal tissue will be exposed to high-dose.  In this study, dosimetric parameters of normal lung tissue were compared between gated and conventional radiotherapy (RT), u...