Song and colleagues deliver a thorough and fair review of the initial clinical investigations of a new paradigm in radiotherapy most recently called stereotactic body radiation therapy (SBRT).[1] Oncology observers may take exception with the use of the designation “new paradigm.” After all, from a tumor control point of view, skeptics might say, “radiotherapy is radiotherapy.” Recent advances ...

There is a clear dose response for localized prostate cancer radiotherapy and there probably is a radiobiological rationale for hypo-fractionation. Combining the two should maximize tumor control and increase the therapeutic ratio. This study examines the rationale and technical feasibility of CyberKnife radiotherapy (a robotic arm-driven linear accelerator) for localized prostate cancer. Its a...

BACKGROUND Increasing the radiotherapy dose can result in improved local control for non-small-cell lung cancer (NSCLC) and can thereby improve survival. Accelerated hypofractionated radiotherapy can expose tumors to a high dose of radiation in a short period of time, but the optimal treatment regimen remains unclear. The purpose of this study was to evaluate the feasibility of utilizing high-d...

Hepatocellular carcinoma (HCC) continues to be one of the worst cancer conditions worldwide, being the sixth most common cancer and associated with a 5-year overall survival rate of only 5% (1). Surgery, either in terms of local resection or liver transplant, is still the treatment of choice, with 5-year survival rates of 30–70% (2). However, o 20% of patients qualify for this treatment because...

The aim of the study was to report the results of radical radiotherapy performed by three-dimensional conformal radiotherapy (3DCRT) for squamous cell carcinoma of the larynx and to compare these data with those obtained with two-dimensional radiotherapy (2DRT) realized with cobalt-60 teletherapy i.e. telecobalt therapy (TCT). Eighty patients with previously untreated laryngeal cancer were irra...

introduction: radiotherapy is a common treatment modality for patients with head and neck malignancies. as the nose lies within the field of radiotherapy of the head and neck, the olfactory fibers and olfactory receptors may be affected by radiation. the aim of this study was to evaluate changes in olfactory threshold in patients with head and neck malignancies who have received radiation to th...

AIM To determine whether any changes in gross tumor volume occur between pre treatment MRI and week 5 MRI in high grade gliomas treated by conformal radiotherapy. METHODS AND MATERIALS Between July 2003-July 2005, 17 patients with WHO grades 3 and 4 malignant gliomas treated with conformal radiotherapy to a total dose of 60 Gy were included in this retrospective study. All patients had underg...

The increased availability of a wide range of sensing technologies over the last few decades has resulted in an equivalent increased need for reliable information fusion methods in machine learning applications. While existing theories such as the Dempster-Shafer theory and the possibility theory have been used for several years now, they do not provide guarantees of error calibration in inform...