intraoperative radiation therapy (iort) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. to evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, iort (15 grays) and postoperative external beam radiotherapy (44 grays). up to 1993, 51 cases o...

after curative treatment of hodgkin’s lymphoma, increased risk of certain solid tumors has been reported. to best of our knowledge this is the first report of metachronous pancreatic adenocarcinoma which developed outside the previous radiation field in a patient with relapse hodgkin’s lymphoma. herein we present an 81-year-old female who developed pancreatic adenocarcinoma four years after the...

background: treatment of ionizing radiation combined with chemical agents can enhance the inactivation of cells. the aim of this study was to determine the parameters involved in the inhibition of cell recovery. materials and methods: a mathematical model describing the process of recovery as a decrease in the effective radiation dose was used. the model includes two parameters, recovery consta...

background: diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. a popular alternative is probiotics, which have been used in several gastrointestinal disorders. probiotics are live microbial food supplements. furthermore, honey is a putative nutritional with a variety of health effects, ...

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background & aim: glioblastoma multiforme (gbm), the highest grade glioma (grade iv), is the most malignant form of astrocytoma in adults. this study aimed at evaluating the relationship between demographic, clinical and medical factors with gbm outcome. methods & materials/patients: through a cross-sectional design, 58 patients with newly diagnosed gbm were studied from 1999 to 2015 in guilan ...

introduction radiotherapy is regarded as the first treatment of choice for nasopharyngeal carcinoma. despite the advantages of radiotherapy, patients may suffer from a wide range of side-effects due to the presence of many sensitive normal tissues in these regions. if the absorbed dose exceeds the tolerance level in parotid glands and the spinal cord, myelopathy, lhermitte's sign and xeros...

background: delivering the maximum dose to tumor while achieving the minimum dose delivery to normal tissue; is the most important goal in external radiotherapy. diode in vivo dosimetry is widely considered to be an important tool for quality improvement of patient care in external radiotherapy. uncertainty in dose delivery should fall within 5% of the prescribed dose as recommended by internat...

background: pulmonary complications of radiation to breast are inevitable, while its incidence and severity are not clear. one of the methods to assess pulmonary complications is spirometry. the influence of radiotherapy on pulmonary function test and the factors affecting it have been assessed in this study. methods: breast cancer patients with stage ii and iii (based on tnm staging), underwen...