Various chemical agents were examined for their radioprotective capability to provide partial protection against radiation injury over the past 50 years. However, no suitable drug has yet been introduced for routine clinical use. In the present study, the radioprotective potential of H2 receptor antagonists was examined in in vivo and in vitro conditions. For this purpose, an in vivo micronucle...

Background: Radioprotective capability of histamine H2 receptor antagonists have been shown in several in vivo studies mainly using animal models. However, to verify the effectiveness of these agents in clinical applications, studies should be performed on human cells. In the present study radioprotective properties of these agents was examined in vitro on human lymphocytes using metaphase anal...

BACKGROUND In many studies, chemicals and natural materials were tested to reduce the harmful effects of radiation. It is known that Famotidine and vitamin C reduce DNA damage. OBJECTIVE The aim of this study was to evaluate the radioprotective effect of vitamin C, Cimetidine and Famotidine on gamma-radiation-induced damage on mouse bone marrow. METHODS Six-to-seven week male NMRI mice (28 ...

the radioprotective effects of vitamin c and famotidine were investigated using the micronucleus test for anticlastogenic and cell proliferation activity. various doses of vitamin c and famotidine were administered intraperitoneally 2 h before 2gy gamma irradiation to nmri adult male mice. frequency of micronuclei in 1000 pces (mnpces) were scored for each sample. cell proliferation ratio (pce/...

Background: Although numerous natural or synthetic drugs have been tested for their radioprotective capacity, yet no suitable drug has been introduced for routine clinical use. In this study the radioprotective effect of "a new herbal immunomodulator" commercially known as IMOD, specifically made to decrease the side effects of HIV virus, was investigated on mouse bone marrow cells. M...

Background: The increasing use of nuclear radiation for human welfare necessitates the search for new, safe, cost effective radio protectors not only for the personnel’s charged with the responsibility of working or testing with radiations in laboratories, but also for general public. With this view the present study has been undertaken to determine the deleterious effects of sub lethal g...

Both protection and sensitization of Mice C57Bl against 60Co gamma-rays by sulfur-containing amino acid derivatives--S-alkyl-L-cysteines, S-alkyl-2-methyl-DL-cysteines and their hydantoin derivatives, and sulfoxides of these compounds--were examined. DL-5 Allylthiomethyl-5-methylhydantoin (150 mg/kg body weight) had a remarkable radioprotective effect. The survival ratio was 4.3 or above two ti...

Diselenonicotinamide (DSNA), a synthetic organoselenium compound, was evaluated for its radioprotective effect in cellular models. A clonogenic assay in Chinese Hamster Ovary (CHO) cells and an apoptosis assay in murine splenic lymphocytes indicated that pre-treatment with DSNA at a concentration of 25 μM significantly protected them from radiation-induced cell death. Upon irradiation (1-12 Gy)...

the present study investigated the radioprotective efficacy of lentil ( lens culinaris ) sprouts against x-ray radiation-induced cellular damage. lentil seeds were dark germinated at low temperature and the sprout extract was prepared in pbs. free radical scavenging of extract was evaluated using 2,2-diphenyl-1-picrylhydrazyl (dpph) assay and then the radioprotective potency of extract (0 to 10...