background: radioprotective effect of famotidine was previously shown on radiation induced micronuclei and chromosomal aberrations in human peripheral lymphocytes and mouse bone marrow cells however, its radioprotective property has never been studied in mouse spermatogenesis. it was also shown that vitamin c as an antioxidant also exert its radioprotective effect on many biological systems, bu...

background: the aim of the present study was to evaluate the radioprotective effect of grewia asiatica fruit pulp extract (gae) on swiss albino mice exposed to gamma radiation. in the present study radioprotective efficacy of grewia asiatica (rich in anthocyanin, carotenes, vitamin c, etc.) was studied against radiation induced biochemical alterations in mice cerebrum. materials and methods: fo...

1Department of Radiation Oncology, Brain Tumor Center of Excellence, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA 2 Institute for Radioprotection and Nuclear Safety, 92262 Fontenay aux Roses Cedex, France 3Vascular Biology Program, Children’s Hospital, Harvard Medical Center, Boston, MA 02115, USA 4Department of Pediatric Oncology, Dana-Fa...

A. Le Guernic,1,2 W. Sanchez,1 S. Betoulle,3 B. Gagnaire2 1Institut National de l’Environnement industriel et des RISques (INERIS), UMR-I 02 SEBIO, Verneuil en Halatte; 2Institut de Radioprotection et de Sûreté Nucléaire (IRSN), pôle environnement, laboratoire d’écotoxicologie des radionucléides, Saint-Paul lez Durance; 3Université de Reims ChampagneArdenne (URCA), UMR-I 02 SEBIO, Reims, France

Previous studies demonstrated that Kit activation confers radioprotection. However, the mechanism by which Kit signaling interferes with cellular response to ionizing radiation (IR) has not been firmly established. Based on the role of the sphingomyelin (SM) cycle apoptotic pathway in IR-induced apoptosis, we hypothesized that one of the Kit signaling components might inhibit IR-induced ceramid...

Exposure to radiation can damage endothelial cells in the irradiated area via the production of reactive oxygen species. We synthesized phosphine-borane complexes that reduce disulfide bonds and had previously been shown to interfere with redox-mediated signaling of cell death. We hypothesized that this class of drugs could interfere with the downstream effects of oxidative stress after irradia...