OBJECTIVE To determine whether combining isosulfan blue dye with a radiopharmaceutical agent will increase intraoperative detection of sentinel nodes (SNs) in patients with early-stage melanoma. PATIENTS AND DESIGN Clinical trial with a consecutive sample. Eighty-seven patients with clinical stage I melanoma underwent preoperative lymphoscintigraphy with 1 of 3 radiopharmaceutical agents to i...

It is most important to assure 4 π−geometry in liquid scintillation counting for accurate results1. Usually this can be assured by dissolution of the sample in an appropriate cocktail. The cocktail does not only contain a solvent but also at least one scintillator and surfactants for aqueous samples because aqueous samples are completely insoluble in the pure organic solvents and scintillators....

18Fluoromethylcholine (18F-Choline, 18F-FCH) has been produced using a home-made automatic synthesiser at 30 MeV Cyclotron Centre, 108 Military Central Hospital. In order to be licensed for patients, the 18F-FCH radiopharmaceutical needs meet required quality specifications listed in pharmacopeia. The objective of this study was build up analytical procedure and perform control followed EuPh201...

The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical 99mTc-MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be easily tested by the concentration data of the radioactive pharmaceuticals in the blood measured at ea...

Introduction: Nuclear Scintigraphy is a highly sensitive, alternative imaging modality used in human and veterinary medicine. This modality involves the administration of a radioactive substance (radioisotope) to a patient. Generally, the radioisotope is labeled to a specific compound. This labeled combination is known as a radiopharmaceutical. These radiopharmaceuticals are formulated in vario...

The off-label use of bevacizumab labeled with 99mTc as a new radiopharmaceutical for imaging of endometriosis is a promising noninvasive, new clinical procedure. The bevacizumab in monoclonal antibodies targeted at vascular endothelial growth factor (VEGF) is superexpressed in cases of endometriosis. In this study we evaluate the imaging of endometriosis lesion in rats (induced to endometriosis...

Introduction In 2016, our center adopted technology to routinely monitor 18 F-FDG radiopharmaceutical administrations. Within six months of following basic quality improvement methodology, technologists reduced extravasation rates from 13.3% 2.9% ( p < 0.0001). These same administer other radiopharmaceuticals (without monitoring technology) for general nuclear medicine procedures in a se...