the features of hypertrophic pulmunary osteoarthropathy (hpoa) on radionuclide bone scintigraphy have been well described in case reports and small series of patients. the aim of this study was to investigate prospectively the prevalence and distribution of hpoa in a large series of patients with carcinoma of the lung. two hundred and eleven patients aged 31-89 years (average age 66 years) male...

Aim: Calculating the absorbed dose is important for the determination of risk and therapeutic benefit of internal radiation therapy. Optimal dose estimations require time-consuming and sophisticated methods, which are difficult due to practical reasons. To make dosimetry available for each of the patients, we developed a specific dosimetry procedure used in daily clinical routine. Materials and...

Introduction Gallium-67 ( 67 Ga) has been used as a radionuclide for imaging a variety of solid tumors since 1969. Since then use of various gallium-based radiotracers has been reported. Recently, 67 Ga-labeled acetylacetate bis(thiosemicarbazones) ( 67 Ga-AATS) complex with significant tumor accumulation and fast blood clearance has been employed. Materials and Methods In this study, the absor...

One of the problems in achieving cures with radioimmunotherapy is that hematological toxicity limits the quantity of radiolabeled monoclonal antibody (MAb) that can be administered. The MAb CC49 binds with high affinity to the TAG-72 antigen expressed in many human adenocarcinomas. We investigated tumor growth inhibition, survival, and tumor and bone marrow dosimetry after multiple bolus inject...

This paper presents dose calculation in proton therapy using Monte Carlo method and comparison with experimental data obtained at TOHOKU University’s cyclotron and isotope center in Japan. In this way, two Monte Carlo codes, FLUKA and MCNPX, has been employed to calculate percentage depth dose, lateral dose profiles, isodose curves and secondary particles production for proton pencil and broad ...

Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed radiopharmaceuticals amount is important. Monte Carlo method is used for simulation of radiation transport in body due to random nature of radiation. In this research, for the first time...

Introduction: Bone metastases are the most common cause of cancer-related pain in various primary malignant tumors, most often, breast and prostate. 188Re-hydroxyethylidene diphosphonate (188Re-HEDP) is a new and less expensive bone seeking radiopharmaceutical with favorable physical characteristics of the radionuclide such as short half life of 16.9h, maximal β energy of ...

This review, using illustrative examples, shows the possibilities of bone scintigraphy as a basic method for examining patients with osteosarcoma in accordance most significant international and domestic recommendations. The material is based on many years experience our own database more than 1000 observations. other radionuclide diagnostic techniques diagnosis monitoring solving various clini...

Purpose: Adequate dosimetry is mandatory for effective and safe peptide receptorradionuclide therapy. The radiation-dose to the bone marrow can be calculated from theresidence time of the radiopeptide in the blood, but it might be underestimated since stemcells express somatostatin-receptors. We verified the blood-method by comparing the resultswith bone marrow aspirations. Also...

large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. therefore, radiation unwanted dose is created in kidney. as a result, exact calculation of prescribed radiopharmaceuticals amount is important. monte carlo method is used for simulation of radiation transport in body due to random nature of radiation. in this research, for the first time...