radiation damage is to a large extent caused by overproduction of reactive oxygen species (ros). radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells. radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the ...

Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. In recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. The aim of the current study was to e...

Background: The fatal effect of ionizing radiation on cells depends on Linear Energy Transfer (LET) level. The distribution of ionizing radiation is sparse and homogeneous for low LET radiations such as X or γ, but it is dense and concentrated for high LET radiation such as heavy-ions radiation. Material and Methods: Chinese hamster ovary cells (CHO-K1) were exposed to 4 Gy Fe-ion 2000 keV/...

Although there are substantial experimental, epidemiological and clinical evidences that high doses of ionizing radiation cause cancer and other detrimental biological effects, the health effects of human exposure to chronic low dose radiation exposures are still poorly known. People in some areas around the world live in dwellings with radiation and radon levels as much as more than 2...

the space environment consists mainly of high-energy charged particles, such as protons, electrons and heavy ions. they are originating from several sources including galactic cosmic radiation, solar flares and van allen belts. high energy electromagnetic radiation and neutrons have also been measured on spacecraft. although shielding can reduce the effect of space radiation it cannot be elimin...

Background: Radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. Materials and Methods: 50 female Wistar rats were randomly divided into 5 groups, average 10 rats/cage: A. control group B. 3Gy×10f C. 6Gy×5f D. 12.5Gy×1f E.15.3Gy×1f....

The concept of matter wave radiation is put forward, and its equation is established for the first time. The formalism solution shows that the probability density is a function of displacement and time. A free particle and a two-level system are reinvestigated considering the effect of matter wave radiation. Three feasible experimental designs, especially a modified Stern-Gerlach setup, are pro...

A classical paradigm [correction of paradym] of radiation biology asserts that all radiation effects on cells, tissues and organisms are due to the direct action of radiation. However, there has been a recent growth of interest in the indirect actions of radiation including the radiation-induced adaptive response, the bystander effect, low-dose hypersensitivity, and genomic instability, which a...