Rabies reappeared in Finland in the spring of 1988 after a 29-year absence. This time rabies occurred in sylvatic form and the major species involved was the raccoon dog. During the outbreak 1988-89 66 animals were diagnosed rabid. Vaccination of cats, cattle and horses was strongly recommended and vaccination of dogs was compulsory in the outbreak area. A field trial was started on oral immuni...

Rabies is a fatal disease in humans, and, to date, the only survivors of the disease have received rabies vaccine before the onset of illness. The approach to management of the rabies normally should be palliative. In unusual circumstances, a decision may be made to use an aggressive approach to therapy for patients who present at an early stage of clinical disease. No single therapeutic agent ...

SCHUMACHER, C.L., COULON, P., LAFAY, F., BENEJEAN, J., AUBERT, M.F.A., BARRAT, J., AUBERT, A. & FLAMAND, A. 1993. SAG-2 oral rabies vaccine. Onderstepoort Journal of Veterinary Research, 60: 458-462 The live modified rabies virus vaccine strain SAG-2 was selected from SAD Berne in a two step process employing anti-rabies glycoprotein monoclonal antibodies. The first two nucleotides coding for t...

The administration of human rabies postexposure prophylaxis near Marseille (southern France) has changed since the eradication of terrestrial mammal rabies in 2001. Most injuries were associated with indigenous dogs; rabies vaccine was overprescribed. We suggest that the World Health Organization guidelines be adapted for countries free of terrestrial mammal rabies.

One of the methods used for controlling cattle rabies in Brazil consists of vaccination. Sometimes, however, rabies occurs in cattle supposedly protected. Since rabies vaccine batches are officially controlled by tests performed on laboratory animals, it is questionable whether the minimal mandatory requirements really correspond to immunogenicity in the target species. We have analyzed the ass...

A new approach to the production and delivery of vaccine antigens is the use of engineered amino virus-based vectors. A chimeric peptide containing antigenic determinants from rabies virus glycoprotein (G protein) (amino acids 253-275) and nucleoprotein (N protein) (amino acids 404-418) was PCR-amplified and cloned as a translational fusion product with the alfalfa mosaic virus (AlMV) coat prot...

OBJECTIVE To determine effect of route of challenge and strain of rabies virus on efficacy of inactivated rabies vaccines in mice. ANIMALS 3,056 mice. PROCEDURE Challenge was performed with fixed and street rabies virus strains by use of footpad and intracerebral routes as well as IM injection into the hip, shoulder, neck, and masseter muscles. Intraperitoneal and IM vaccination was perform...

OBJECTIVE To evaluate the effectiveness of intervention efforts to halt 2 wildlife rabies epizootics from 1995 through 2003, including 9 oral rabies vaccination campaigns for coyotes and 8 oral rabies vaccination campaigns for gray foxes. DESIGN Retrospective study. ANIMALS 98 coyotes during prevaccination surveillance and 963 coyotes and 104 nontarget animals during postvaccination surveil...

rabies is acutely fatal encephalitis caused by a neurotropic virus. this virus belongs to the family ofrhabdoviridae and genus of lyssavirus. the virus is almost always transmitted to human through infectedmammalian saliva. rabies is inoculated to a wound by an infected animal bite. since infection is establishedin the cns, the outcome is almost always fatal. according to the outstanding role o...

Rabies is a virtually 100% fatal acute viral encephalitis. Rabies occurs in more than 150 countries and territories. Globally there are 17.4 million animal bite cases and more than 55,000 deaths annually. India's 20,000 deaths accounts for 36% of global and 65% of the Asian (31,000) deaths. The Intradermal Rabies Vaccine (IDRV) was first started in Thailand in 1984. In 1992, World Health Organi...