Psoriasis is a refractory and difficult-to-treat skin disorder. Neutrophil-targeting approach represents promising option for psoriasis therapy. This study developed examined NIMP-R14-conjugated immunonanoparticles specific targeting to neutrophils associated with psoriasiform dermatitis. In the process, roflumilast (RFL), as phosphodiesterase (PDE) 4 inhibitor, was encapsulated into nanocarrie...

1 2 Neutrophils are key components of the inflammatory response and as such contribute to the 3 killing of microorganisms. In addition, recent evidence suggests their involvement in the 4 development of the immune response. The role of neutrophils during the first weeks post 5 infection with Leishmania donovani was investigated in this study. When L. donovani6 infected mice were selectively dep...

Using a system of structural equations, this paper empirically examines the relationship of residential neighborhood type to travel behavior, incorporating attitudinal, lifestyle, and demographic variables. Data on these variables were collected from residents of five neighborhoods in the San Francisco Bay Area in 1993 (final N 1⁄4 515), including ‘‘traditional’’ and ‘‘suburban’’ as well as mix...

This paper assesses the impact of Siam’s 1901 Land Title Deed Act on land markets and land use in Bangkok. Using a sample of orchard title deeds issued in the 1880s, this study investigates the incidence of land transfers and subsequent land use patterns both before and after the transition from usufruct to full private ownership rights as a result of the 1901 Act. Survival analysis shows that ...

The dynamic interplay between kinases and substrates is crucial for the formation of catalytically committed complexes that enable phosphoryl transfer. However, a clear understanding on how substrates modulate kinase structural dynamics to control catalytic efficiency is still missing. Here, we used solution NMR spectroscopy to study the conformational dynamics of two complexes of the catalytic...

The purpose of this study was to investigate the effect of reloading on atrophied muscle and the time course of hypertrophy and regeneration. Forty-nine male Wistar rats were randomly assigned to groups for hindlimb suspension (HS), hindlimb suspension and reloading (R), or control (C0). Rats in the HS group were suspended for 14 days. Rats in the R group were randomly divided into five subgrou...

Solar observations of carbon monoxide (CO) indicate the existence lower-temperature gas in lower solar chromosphere. We present an observation pores, and quiet-Sun, network magnetic field regions with CO 4.66 {\mu}m lines by Cryogenic Infrared Spectrograph (CYRA) at Big Bear Observatory. used strong around to understand properties thermal structures atmosphere different features various strengt...

Search, Migration, and Urban Land Use: The Case of Transportation Policies We develop a search-matching model with rural-urban migration and an explicit land market. Wages, job creation, urban housing prices are endogenous and we characterize the steadystate equilibrium. We then consider three different policies: a transportation policy that improves the public transport system in the city, an ...