Nucleophilic substitution reactions of 2-halo-2H-azirines 1a, 1b, 1d, and 1e with potassium phthalimide and aniline allowed the preparation of new substituted 2H-azirines 2-5. The reactions of 2-bromo-2H-azirine 1a with methylamine led to the synthesis of alpha-diimines 7 and 8. 2-Halo-2H-azirines were also established as building blocks for the synthesis of a range of heterocyclic compounds, n...

Four new quinoxaline-spanned cavitands having a diester hydrogen phosphate group were successfully synthesised. These phosphorous derivatives applied in Brønsted acid-assisted catalytic conjugate addition reactions. The results ranked with the control of diphenyl as well among those four cavitands. structure–activity relationship revealed that catalyst centre surrounded by two trans-positioned ...

la(oac)3 has been used as an efficient catalytic system for the synthesis of quinoxalines. this method provides several advantages over methods that are currently employed such as a simple work-up, mild reaction conditions, good to excellent yields, and a process to recover and reuse the catalyst for five cycles with consistent activity.

The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutations affecting the NNRTI-binding pocket, and five of six strains displayed the RT G190-->E substitution, which is characteristic for HIV-1 resistan...

In this research, by a simple and modified method, nanoporous of Ni(II) ion loaded Y-type zeolite (NNZ) was designed and applied as a novel highly efficient catalyst for the synthesis of quinoxalines, pyrido[2,3-b]pyrazines, and indolo[2,3-b]quinoxalines 3a-s. These heterocycles were obtained through a one-pot condensation reaction of aryl-1,2-diamines with 1,2-dik...

An efficient and mild synthesis of quinoxalines in cludingcyclo-condensation of 1, 2-phenylenediamine and 1, 2-diketonesin the presence of1mol% catalytic amount of SnO2 nanoparticles (1 mol%) in water at room temperature is established. On the whole, this study introduced at this point is substantial in terms of using water as solvent, low reaction time (5 to 10 minutes), high yields...