The Friedländer reactions of acetylbenzenes and 2-acetylpyridine with 3-aminonaphthalene-2-carbaldehyde afforded the corresponding 2-phenylbenzo[g]quinoline and 2-(pyrid-2-yl)benzo[g]quinoline, respectively. The same reactions of 3-aminonaphthalene-2-carbaldehyde with 1,2-, 1,3-, 1,4-di- and 1,3,5-triacetylbenzenes, however, afforded a series of corresponding (benzo[g]quinolin-2-yl)benzenes as ...

It has been found that certain urinary quinoline derivatives could be eluted from Dowex 50 (H+) columns by washing with a large volume of water (l-3). The present study concerns an examination of urine from normal swine and rabbits for various quinoline derivatives. Seven quinoline derivatives were identified in the urine of these two species, including two apparently new urinary products and t...

A series of novel quinoline-3-carboxamide derivatives 10-17 and 23-27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.

In the title mol-ecule, C(28)H(20)Cl(2)N(2)O(2), the dihedral angle between the 2-chloro-quinoline and 6-chloro-quinoline rings is 7.55 (6)°. The dihedral angle between the phenyl ring and its attached quinoline ring is 62.59 (4)°. In the crystal, aromatic π-π stacking inter-actions [centroid-centroid distances = 3.771 (3) and 3.612 (3) Å] help to establish the packing.

Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. A...

In vivo 4-hydroxyamino[2-3H]quinoline 1-oxide-modified DNA and in vitro 4-acetoxyamino[2-3H]quinoline 1-oxide-modified DNA were enzymatically hydrolyzed, and the hydrolysates were analyzed by high-performance liquid chromatography. The two patterns were compared, and we showed that all of the high-performance liquid chromatography peaks which were recovered from in vivo-modified DNA were presen...

OBJECTIVE To study the degradation of pyridine and quinoline by two Pseudomonas. METHODS Based on the analysis of 16S rRNA gene sequence homology and the intergenic spacer region sequence, the two isolates were identified. The degradation capability of pyridine and quinoline was determined according to spectrophotometry and Electrospray Ionisation/Mass Spectrometry (ESI/MS). The degrading pla...

Anoxybacillus rupiensis Ir2 (JQ912240), thermophilic bacteria capable of utilizing aromatic hydrocarbon especially N-compounds that form part of petroleum components.In an attempt to investigate the ability of this bacterium to degrade quinoline and indole, the strain Ir2 was grown on these N-compounds separately as a sole source of carbon and nitrogen. Results showed that strain Ir2 was able t...

The title compound, [Ru(C10H8N2)2(C16H12N4O)](BF4)2·3CH2Cl2, crystallizes with one complex dication, two BF4 (-) counter-anions and three di-chloro-methane solvent mol-ecules in the asymmetric unit. The central Ru(II) atom adopts a distorted octa-hedral coordination sphere with two 2,2'-bi-pyridine (bpy) and one quinoline-2-carbaldehyde (pyridine-2-carbon-yl)hydrazone (HL) ligand. The hydrazone...