The asymmetric unit of the title quinazolinone compound, C(16)H(13)ClN(2)OS, consists of two crystallographically independent mol-ecules, A and B. The dihedral angles between the quinazoline and benzene rings are 16.88 (6) and 32.34 (6)° for mol-ecules A and B, respectively. In the crystal structure, mol-ecules A and B are linked by two bifurcated inter-molecular N-H⋯S and C-H⋯S hydrogen bonds....

In the title hydrated mol-ecular salt, C(9)H(10)N(3)O(+)·C(7)H(7)O(3)S(-)·H(2)O, the cation is protonated at a quinazolinone N atom and an intra-molecular N-H⋯O hydrogen bond occurs. In the crystal structure, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds and C-H⋯O, C-H⋯π and weak aromatic π-π stacking inter-actions [centroid-centroid separations = 3.8648 (12) and 3.9306 (13) Å] help to establi...

In search of potent inhibitors cholinesterase enzymes and antioxidant agents, synthetic derivatives dihydroquinazolin-4(1H)-one 1-38 were evaluated as potential anti-Alzheimer agents through in vitro acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inhibitions radical (DPPH ABTS) scavenging activities. The (SAR) was mainly based on the different substituents at aryl part which showed a ...

Quinazoline and quinazolinone derivatives display an extensive application in organic pharmaceutical chemistry, they have been used as natural synthetic materials for medicinal chemistry purposes. Here I reported investigation of a new series quinazolin-4(3H)-one ring derivatives. In this context, starting from the methyl anthranilate, six (4a-f) with various aminomethyl moieties at position 2 ...

Azalactone 1 can be synthesized via treatment of 4chlorobenzoyl glycine with p-anisaldehyde in the presence of acetic anhydride and sod Acetate. The behaviour of azalactone 1 towards nitrogen nucleophiles, for example, anthranilic acid, 6-aminopyrimidin-2,4-dione and 2-amino-6-phenyl 1,3,4thiadiazole can be investigated. Benzoxazone 2 can be treated with hydrazine hydrate, hydroxylamine hydroch...

Effects of MCI-176, 2-(2,5-dimethoxyphenylmethyl)-3-(2-dimethylaminoethyl)-6-isopropox y-4 (3H)-quinazolinone hydrochloride, on coronary and aortic blood flows, mean blood pressure and heart rate were investigated in comparison with those of diltiazem in anesthetized dogs. MCI-176, like diltiazem, dose-dependently increased coronary and aortic blood flows and decreased mean blood pressure. In p...