Various attempts have been made in the literature at describing origin and physical mechanisms behind flaring events blazars with radiative emission models, but detailed properties of multi-wavelength (MWL) light curves still remain difficult to reproduce. We developed a versatile code, based on time-dependent treatment particle acceleration, escape cooling, allowing us test different scenarios...

Somata of pacemaker and nonpacemaker neurons were isolated by ligatures tied around the axons between the somata and the synaptic regions, and the transmembrane potentials of the isolated somata were recorded. Isolated somata of pacemaker neurons had a spontaneous discharge while isolated somata of nonpacemaker neurons were quiescent. In addition, the time course of accommodation in isolated so...

We examined the postnatal consequences of removing Hedgehog signaling within the adult stem cell niche. Although at birth the subventricular zone appears normal in mice lacking Hedgehog signaling, by postnatal day 8 it is greatly impaired, and cell death is increased. In addition, both the quiescent B stem cell population and transit-amplifying C cells become depleted postnatally. In contrast, ...

We study the problem of achieving reliable communication with quiescent algorithms (i.e., algorithms that eventually stop sending messages) in asynchronous systems with process crashes and lossy links. We first show that it is impossible to solve this problem in asynchronous systems (with no failure detectors). We then show that, among failure detectors that output lists of suspects, the weakes...

The scarcity of tissue-specific stem cells and the complexity of their surrounding environment have made molecular characterization of these cells particularly challenging. Through single-cell transcriptome and weighted gene co-expression network analysis (WGCNA), we uncovered molecular properties of CD133(+)/GFAP(-) ependymal (E) cells in the adult mouse forebrain neurogenic zone. Surprisingly...

The limited generation of neurons during adulthood is controlled by a balance between quiescence and recruitment of neural stem cells (NSCs). We use here the germinal zone of the zebrafish adult telencephalon to examine how the frequency of NSC divisions is regulated. We show, using several in vivo techniques, that progenitors transit back and forth between the quiescent and dividing state, acc...